Autonomic and Neuromuscular Pharmacology Flashcards
acetylcholine works on
cholinergic receptors:
nicotinic and muscarinic
noradrenaline and adrenaline act on
adrenergic receptors:
alpha 1+2, beta 1+2
using drugs that target ganglia
not a good idea- will affect sympathetic and parasympathetic as all use same neurotransmitter and receptor
synaptic transmission 1
neurotransmitter is made in presynaptic terminal
synaptic transmission 2
Na+ action potential reaches end terminal
and activates voltage gated Ca2+ channels
synaptic transmission 3
Ca2+ triggers exocytosis of the vesicles of neurotransmitter- and it enters the synapse
synaptic transmission 4
neurotransmitter diffuses across and binds to ionotropic and/or metabotropic receptors
and trigger the post synapting response
synaptic transmission 5
presenting autoreceptors inhibit anymore NT release
synaptic transmission 6
NT left in synapse is inactivated by uptake into glia or neurones
synaptic transmission 8
NT is metabolised in the cell
clinical applications: non-depolarising or depolarising blockers are used for
paralysis during:
surgery
ECF
spasms in tetanus
clinical applications: botulinum toxin used for
treating spasm
cosmetic procedures
clinical applications: anticholinesterases
treats myasthenic syndromes
reverses action of non-depolarizing blockers
counters botulinum poisoning