Autonomic and Neuromuscular Pharmacology Flashcards

1
Q

acetylcholine works on

A

cholinergic receptors:
nicotinic and muscarinic

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2
Q

noradrenaline and adrenaline act on

A

adrenergic receptors:

alpha 1+2, beta 1+2

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3
Q

using drugs that target ganglia

A

not a good idea- will affect sympathetic and parasympathetic as all use same neurotransmitter and receptor

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4
Q

synaptic transmission 1

A

neurotransmitter is made in presynaptic terminal

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5
Q

synaptic transmission 2

A

Na+ action potential reaches end terminal

and activates voltage gated Ca2+ channels

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6
Q

synaptic transmission 3

A

Ca2+ triggers exocytosis of the vesicles of neurotransmitter- and it enters the synapse

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7
Q

synaptic transmission 4

A

neurotransmitter diffuses across and binds to ionotropic and/or metabotropic receptors

and trigger the post synapting response

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8
Q

synaptic transmission 5

A

presenting autoreceptors inhibit anymore NT release

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9
Q

synaptic transmission 6

A

NT left in synapse is inactivated by uptake into glia or neurones

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10
Q

synaptic transmission 8

A

NT is metabolised in the cell

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11
Q

clinical applications: non-depolarising or depolarising blockers are used for

A

paralysis during:

surgery

ECF

spasms in tetanus

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12
Q

clinical applications: botulinum toxin used for

A

treating spasm

cosmetic procedures

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13
Q

clinical applications: anticholinesterases

A

treats myasthenic syndromes

reverses action of non-depolarizing blockers

counters botulinum poisoning

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