Autoimmunity Flashcards
What are the clinical features of Hashimoto’s Hypothyroidism?
Goitre Sx/signs of hypothyroidism -fatigue, constipation, wt gain, dry skin -cold intolerance -slowed movement, loss of energy -decreased sweating -mild nerve deafness -peripheral neuropathy -menstrual irregularities -depression, dementia, memory loss -hair loss
What lab test results are associated with Hashimoto’s Hypothyroidism?
Raised TSH
Anti-TPO & Anti-Tg antibiodies present
What are the clinical features of Pernicious Anaemia?
Sx of Anaemia Pallor Heart failure Neurological Sx -loss of vibratory sense/position -spasticity -impairment of pain/temp/touch -yellow/blue blindnress -psychiatric sx
What lab test results are associated with Pernicious Anaemia?
Macrocytic anaemia Low Vit B12 Increased bilirubin Autoantibiody screen (IFABs) Gastric anti-parietal cell antibodies
What are the clinical features of Systemic Lupus Erythematous?
Nonspecific Sx -fatigue, malaise, fever -splenomegaly, lympahdenopathy -Raynaud's phenomenon Arthralgia Secondary fibromyalgia Mucocutaneous Sx Wide range of systemic sx
What are the diagnostic criteria for SLE?
4 or more of
- malar rash
- discoid lupus
- photosensitivity
- oral/nasopharyngeal ulcers
- non-erosive arthritis
- pleuritis/pericarditis
- renal involement
- seizures/psychosis
- haematological disorder
- immunological disorders
- +ve antinuclear antibody
What lab test results are associated with SLE?
FBC/ESR - mild normochromic, normocytic anaemia w/ raised ESR Autoantibodies -ANA -Anti-dsDNA -Anti-Sm -Anti-SSa/SSB -Anti-ribosomal P -Anti-RNP -Anti-histone
What are the clinical features of Rheumatoid Arthritis?
Arthritic Sx Systemic manifestations -leg ulcers -rheumatoid nodules -peripheral nerve entrapment -pulmonary/myocardial fibrosis -valvulitis -hepatomegaly -thyroid disorders
What lab test results are associated with RA?
FBC - normochromic, normocytic anaemia w/ reactive thrombocytosis
Rheumatoid factor
Anti-CCP antibodies
What are the clinical features of Coeliac Disease?
Altered bowel habits Faltering growth Prolonged fatigue Unexpected weight loss Severe/persistent mouth ulcers Fe/B12/Folate deficiencies T1DM AI Thyroid disease IBS 1st degree relatives w/ Coeliacs
What are the lab test results associated with Coeliac Disease?
FBC - anaemia CD-specific auto antibodies -IgA tTG -IgG EMA/DGP/tTG -HLA DQ2
