Autoimmunity

Question 1

Lupus presentations

Answer 1

Malar rash, arthritis, kidney problems

Question 2

Cause of kidney problems in lupus

Answer 2

Immune complex deposition in glomeruli –> space around capillaries crowded
Thickened walls of capillaries –> “wire loop”

Question 3

Antibodies to test for lupus

Answer 3

Anti-Sm and Anti-dsDNA

Question 4

First manifestation of systemic sclerosis

Answer 4

Puffy fingers

Question 5

Systemic sclerosis microscopic pathology in skin

Answer 5

Fibrous expansion of dermis and loss of dermal appendages

Question 6

Systemic sclerosis microscopic pathology in renal capillaries

Answer 6

Concentric sclerosing intimal thickening –> onion skinning

Question 7

Sjogren syndrome microscopic pathology

Answer 7

Lymphocytes attacking lacrimal/salivary glands

Question 8

Post transplant lymphoproliferative disorder

Answer 8

EBV in transplanted organ activates and causes lymphoma

Question 9

Acute cellular rejection of transplant

Answer 9

CD8 T cells invade and attack transplanted tissue

Question 10

Acute humoral rejection in transplant

Answer 10

Immunostain for C4d shows complement deposition

Question 11

Calcineurin inhibitors and kidney transplant

Answer 11

Immunosuppressant that has renal toxicity. transplanted organ must be evaluated for damage.

1. Isometric vacuoloization of tubular epithelial cell cytoplasm
2. Tubular calcifications
3. Giant mitochondria

Question 12

Grafts versus host disease

Answer 12

Attack of host organs by transplanted organ