Autoimmune Skin Conditions Flashcards
what diagnostic test is used for autoimmune blistering conditions
biopsy with immunofluorescence
itchy, large, tense blisters
bullous pemphigoid
non-itchy flaccid blisters that burst easily
pemphigus vulgaris
where in the skin are the blisters in bullous pemphigoid?
deeper blister - subepidermal split through basement membrane
where in the skin are blisters in pemphigus vulgaris
superficial blisters - intradermal split just above basal layer
immunofluoresence result in pemphigoid
linear IgG deposits at dermo-epidermal junction
immunofluorescence result in pemphigus
IgG deposition in chickenwire pattern
- junctions between keratinocytes are attacked
what is nikolsky’s sign?
can seperate superficial skin layer by gentle rubbing the skin
which condition is nikolsky’s sign +ve : pemphoid or pemphigus?
pemphigus
what is often the first sign in pemphigus vulgaris
mucosal blistering
what are the antibodies against in pemphigus vulgaris
desmogleins
what are the antibodies against in bullous pemphigoid
collagen and dystonin
treatment of pemphigus vulgaris
high dose oral prednisolone
other immunosuppressants that can be used:
- azathioprine
- cyclophosphamide
- rituximab
treatment for bullous pemphigoid if
- localised
- extensive
localised: topical steroids
extensive: oral prednisolone
intensely itchy papulovesicular rash on extensors/buttocks
suggestive of?
dermatitis herpetiformis
