Autoimmune Epilepsy Flashcards
What antibody that causes adult onset,frequent brief dystonic seizures that predominantly affect the arm and ipsilateral face?
Antibody is to VGKC complexes, antigenic target is LGI1.
What type of seizures are associated with anti-LGI1 encephalitis?
Faciobrachial dystonic seizures (FBDS)
What is the usual clinical progression of anti-NMDAR encephalitis?
Progression of psychosis, memory deficits, seizures, and language disintegration to a state of unresponsiveness with catatonic features often associated abnormal movements and autonomic and breathing instabilities.
What age range predominates anti-NMDR encephalitis?
Children and young adults
Can anti-NMDR encephalitis occur without tumor?
Yes, with or without tumor
What tumor is associated with anti-NMDR encephalitis?
Ovarian teratoma
What type of abnormal movements are seen in anti-NMDR encephalitis?
Oro-lingual-facial dyskinesia
What type of seizures are seen in anti-NMDR encephalitis?
Motor and complex seizures, including status epilepticus.
What autoimmune dz gives rise to limbic encephalitis?
Anti-AMPA with antibodies to GluR1 and GluR2 subunits
What subunits are associated with anti-AMPA encephalitis?
GluR1 and GluR2
Anti-AMPA encephalitis is associated with limbic encephalitis and what other symptoms?
Acute psychosis and aphasia
What receptor antibody is associated with Rasmussen encephalitis?
Anti-GluR3
What clinical symptoms are associated with Rasmussen?
EPC, progressive hemiplegia, hemiatrophy
Anti-GABAB receptor antibodies with what clinical symptoms?
Limbic encephalitis, seizures, memory loss, and confusion.
Anti-GABAB is associated with what other clinical symptoms?
Ataxia, opsoclonus-myoclonus, with and without tremor
