Autoimmune disease

Question 1

Goodpasture’s Syndrome- type?

1. Autoantigen
2. Sx

Answer 1

Type II

1. Non collagenous part of basement membrane; collagen Type IV
2. glomerulonephritis, pulmonary hemorrhage

Question 1

Autoimmune against receptors

What are they (antagonist/agonist) (x4)

Answer 1

Type II

1. Myasthenia gravis= Ach R antagonist; muscle weakness
2. Diabetes Mellitis (2)= InsulinR antagonist- hyperglycemia, ketoacidosis
3. Graves= TSH R agonist- hyperthyroidism
4. Hypoglycemis= Insulin R agonist= hypogelycemia

Question 2

Autoimmune Hemolytic anemia- type?

1. Autoantigen
2. Sx

Answer 2

Type II

1. Rh blood group antigens, I antigen
2. RBC destruction by complement and phagocytosis= anemia

Question 3

Type IV=

Answer 3

1. Type I DM= beta cell antigen= destruction of beta cells- no insulin
2. Rheumatoid Arthritis= synovial joint inflammtion
3. MS=myelin peptide Ag= brain degeneration and paralysis

Question 4

Pemphigus foliaceustype?

1. Autoantigen
2. Sx

Answer 4

Type II

1. desmoglein
2. mild blistering

Question 5

Pemphigus foliaceus-type?

1. Autoantigen
2. Sx

Answer 5

Type II

1. desmoglein
2. mild blistering

Question 6

Type III autoimmune (x3)-Autoantigen, presentaion

Answer 6

1. Subacute bacterial endocarditis= to bacterial antigen, glomerulonephritis
2. Mixed essential cryoglobinemia- Rheutoid factor IgG complexes= vasculitis
3. Systemic Lupus= autoantigens are DNA, histones, RNA, ect; vasculitis, glomerulonephritis, arthritis.

Question 7

Pemphigus Vulgaris- type?

1. Autoantigen
2. Sx

Answer 7

Type II

1. epidermal cadherin
2. blistering

Question 9

Rheumatic fever

1. Autoantigen
2. Sx

Answer 9

Type II

1. strep antigens cross react with
2. arthritis, myocarditis, heart valve scarring

Question 10

Autoimmune thrombocytopenia purpura- type?

1. Autoantigen
2. Sx

Answer 10

Type II

1. Platelet integrin gpIIb:IIIa
2. abnormal bleeding