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Lab diagnostics > Autoimmune > Flashcards

Autoimmune Flashcards

1
Q

ANA is used to:

A

detect and monitor autoimmune disorders

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2
Q

What are the primary diseases associated with ANA?

A

MCTDs and SLE

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3
Q

What else could cause an elevated ANA?

A

autoimmune disease, RA, scleroderma, RA , sjogren and polimelitis

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4
Q

How is ANA tested?

A

fluorescein stain - measuring the titers and pattern

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5
Q

Homogenous ANA means?

A

SLE and MCTDs

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6
Q

Speckled ANA means?

A

SLE, MCTDs, scleroderma, RA, Sjogren’s, poliomyelitis

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7
Q

Nucleolar ANA means?

A

poliomyelitis, scleroderma

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8
Q

periphery ANA means?

A

SLE

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9
Q

What is RA less sensitive for?

A

Early RA

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10
Q

What would be indicated with a high RF?

A

RA, autoimmune diseases (SLE and Hep C)

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11
Q

What markers are increased in inflammation?

A

CRP, ESR

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12
Q

Which marker is indicative of CREST syndrome?

A

Anticentromere antibody

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13
Q

What is anticentromere antibody sensitive for?

A

CREST syndrome but NOT scleroderma

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14
Q

is CRP or ESR more sensitive?

A

CRP

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15
Q

What is released with necrotic tissue? (it is bound to it)

A

CRP

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16
Q

What is CRP?

A

non specific indicator of inflammation

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17
Q

What is ESR an indicator of?

A

non specific indicator of inflammation

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18
Q

What is ESR a measure of?

A

the amount of time that it takes for the RBCs to settle into plasma or saline

19
Q

what test is elevated in patients with antiphospholipid syndrome associated with thrombosis, thrombocytopenia, CVA, multiple miscarriages

A

anticardiolipin antibody

20
Q

What diseases are associated with anticardiolipin antibody?

A

antiphospholipid syndrome and SLE

21
Q

If a patient presents with Calcinosis, Raynauds, esophageal syndrome, sclerodactyly, telangiectasia, what test would you perform?

A

anticentromere antibody

22
Q

What test can be performed to test for SLE but usually just performed to rule out renal involvement with SLE patients?

A

anti-nucleosome (anti- NCS)

23
Q

if a patient’s anti double strand DNA is highly elevated what would that mean?

A

good chance of SLE

24
Q

If a patient anti- double stranded (Anti-ds DNA) is slightly elevated what would you use to confirm lupus dx?

A

antinuceosome (anti-ncs)

25
Q

if you have a positive ANA and a negative anti-smith what would be the disease?

A

MCTDs

26
Q

What is Anti-CCP be used to test?

A

early RA (used in conjunction with RF)

27
Q

What test tests for SLE and MCTDs ?

A

ANA and Anti- ENA

28
Q

What does anti-smith test for?

A

SLE

29
Q

What test checks for renal involvement in SLE ?

A

anti nucleosome (anti- ncs)

30
Q

what test is used to diagnose and monitor SLE?

A

anti-double strand DNA (anti- ds DNA)

31
Q

What tests for SLE and MCTDs ?

A

anti-extractable nuclear antigen

32
Q

What test tests for SLE only

A

anti-smith

33
Q

if ANA is positive and you perform a anti extractable nuclear antigen and the anti smith is positive , what could it be?

A

SLE

34
Q

Anti-mitochondrial antibody (AMA) is used to test what?

A

diagnose primary biliary cirrhosis

35
Q

What do you need to diagnose hepatobiliary cirrhosis?

A

AMA and liver biopsy

36
Q

What does ASMA do?

A

detects the difference between autoimmune hepatitis and SLE

37
Q

What does AMA do?

A

diagnosis primary biliary cirrhosis

38
Q

What does ANCA test for?

A

diagnose wegener’s granulomatosis

39
Q

What are the 2 staining patterns for ANCA?

A

P-ANCA (perinuclear)

C-ANCA (cytoplasm)

40
Q

Anti scleroderma antibody (Sc- 70 antibody) tests for what?

A

PSS with confirmatory biopsy

41
Q

What does a negative SC-70 mean?

A

does not necessarily mean that it is negative for PSS (progressive systemic scleroderma)

42
Q

If there is symptoms of sjrogens and Anti SS-A (Ro) is positive, what needs to be positive for a confirmation in diagnosis?

A

Anti-SS-B (la)

43
Q

What does Anti-SS-C test for?

A

RA and sjogrens

Lab diagnostics (6 decks)

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