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Theo's Path > Autoantibodies, HLA associations and polymorphisms > Flashcards

Autoantibodies, HLA associations and polymorphisms Flashcards

1
Q

HLA B27

A

A. Ankylosing spondylitis

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2
Q

HLA DR15/DR2

A

A. Goodpasture’s

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3
Q

HLA-DR3

A

A. Graves disease, SLE, T1DM

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4
Q

HLA-DR3/DR4

A

A. T1DM

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5
Q

HLA-DR4

A

A. Rheumatoid arthritis

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6
Q

PTPN22

A

A. RA, SLE, T1DM

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7
Q

CTLA4

A

A. SLE, T1DM, autoimmune thyroid dx

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8
Q

Cardiolipin, B2 glycoprotein and lupus anticoagulant

A

A. Antiphospholipid syndrome

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9
Q

Anti-SM, anti-LKM1 and anti-SLA

A

A. Autoimmune hepatitis

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10
Q

Anti-Rh

A

A. Autoimmune haemolytic anaemia

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11
Q

Anti-GpIIb/IIIa or Ib-IX

A

A. AITP

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12
Q

Anti-TGT, anti-EMA (both IgA)

A

A. Coeliac dx

95% have DQ2 or DQ8 (DQ2>DQ8)
Associated with dermatitis herpetiformis (chronic, itchy, blistering skin rash resembling herpes)

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13
Q

Anti-Ro

A

A. Congenital heart block (maternal SLE)

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14
Q

Anti-EMA (IgA)

A

A. Dermatitis herpetiformis

+anti-TGT = Coeliac dx

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15
Q

Anti-Jo1

A

A. Dermatomyositis and polymyositis

dermatomyositis has skin involvement e.g. heliotrope rash

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16
Q

Anti-topoisomerase/Scl70
RNA Pol I, II, III
Fibrallin

A

A. Diffuse cutaneous scleroderma (CREST+)

CREST + interstitial pulmonary disease and renal problems

17
Q

Anti-GBM

HLA DR15/DR2

A

A. Goodpasture’s

18
Q

Anti-TSHR

HLA-DR3

A

A. Graves dx

19
Q

Anti-Thyroglobulin and Thyroperoxidase

A

A. Hashimoto’s

20
Q

Anti-centromere

A

A. Limited cutaneous scleroderma/CREST

Calcinosis
Raynaud's
Oesophageal dysmotility 
Sclerodactyly 
Telangiectasia
21
Q

p-ANCA

A

A. Microscopic polyangitis and eGPA

22
Q

Anti-U1RNP

A

A. Mixed connective tissue disease

23
Q

Anti-ACh

A

A. Myasthenia Gravis

24
Q

Anti-mitochondrial

A

A. Primary biliary cirrhosis

More common in women

25
Q

Anti-CCP

A

A. Rheumatoid arthritis

HLA-DR4, rheumatoid factor

26
Q

Anti-Ro, Anti-La

60% have RF+

A

A. Sjogren’s syndrome

More common in women
Dry mouth, eyes, nose and skin - may have systemic involvement

27
Q

X-linked recessive disorder affecting males only. Associated with eczematous dermatitis, nail dystrophy and alopecia. Most children die within 2 years of life.

A

A. IPEX syndrome

Immune dysregulation 
Polyendocrinopathy 
Enteropathy 
X-linked 
\+ autoimmune dx

Mx - BMT

28
Q

Anti-dsDNA

HLA-DR3

A

A. SLE

29
Q

Anti-GAD

A

A. T1DM

30
Q

c-ANCA

A

A. Wegener’s (GPA)

Theo's Path (9 decks)

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