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Paddy Phase 2 Qs > Autoantibodies! (FFS) > Flashcards

Autoantibodies! (FFS) Flashcards

1
Q

Which autoantibody has the highest specificity for Rheumatoid Arthritis?

A

Anticyclic citrullinated Peptide antibody (Anti-CCP)

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2
Q

Which conditions might you find Antinuclear Antibody positive? (5) Which has the highest amount?

A 
SLE - more than 95%
Autoimmune Hepatitis
Sjogrens Syndrome
Systemic Sclerosis (96%)
Rheumatoid Arthritis
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3
Q

How can antibodies be seen by microbiologists?

A

Staining techniques such as immunofluorescence

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4
Q

Which autoantibody is highly specific to Systemic Luper Erythematousus?

A

Anti-double stranded DNA (Anti dsDNA)

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5
Q

Which autoantibody is specific to antiphospholipid syndrome?

A

Antiphospholipid Antibody (also for SLE)

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6
Q

Which autoantibody is specific to systemic sclerosis?

A

Anti centromere antibody

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7
Q

What are Anti-Ro (SSA) antibodies an indicator of?

A

SLE, Sjogrens Syndrome, Systemic Sclerosis

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8
Q

What are Anti-La (SSB) antibodies an indicator of?

A

Sjogrens syndrome, SLE

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9
Q

Which antibodies other than Anti dsDNA, anti-la and Anti Ro, and antiphospholipid may indicate SLE?

A

Anti Sm, Anti RNP

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10
Q

What antibody might be raised in somebody with primary biliary cholangitis?

A

Anti Mitochondrial Antibody (AMA) (Also anti smooth muscle antibody)

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11
Q

What antibody might be raised in somebody with autoimmune hepatitis?

A

Anti Smooth Muscle Antibody (also antimitochondrial antibody)

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12
Q

What antibodies might be raised in somebody with pernicious anaemia?

A

Gastric Parietal Cell Antibody and Intrinsic Factor Antibody

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13
Q

Which antibodies could be raised in somebody with coeliac disease? (3)

A

alpha-gliandin antibody, antitissue transglutaminase, anti-endomysial antibody

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14
Q

What antibody may be raised in somebody with Hashimoto’s Thyroiditis? What other disease might have this antibody?

A

Thyroid Peroxidase antibody

Graves Disease

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15
Q

Which antibody would be raised in somebody with Goodpastures Disease?

A

Glomerular Basement Membrane Antibody (anti-GBM)

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16
Q

What could ANCA (anti neutrophil cytoplasmic antibodies) indicate?

A 
Wegners Granulomatosis ( with polyangitis) - if Cytoplasmic (C-ANCA)
Churg Strauss - if Perinuclear (P-ANCA)

ANCA could also be positive in Ulcerative Colitis and Crohns.

17
Q

Which antibody could be raised in myasthenia gravis?

A

Acetylcholine receptor Antibody

Paddy Phase 2 Qs (15 decks)

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