Autoantibodies and Associated Disorder

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin

Answer 3

SLE, antiphospholipid syndrome

Question 4

Lupus anticoagulant

Answer 4

SLE, antiphospholipid syndrome

Question 5

Anticentromere

Answer 5

Limited scleroderma (CREST syndrome)

Question 6

Anti-desmosome (anti-desmoglein)

Answer 6

Pemphigus vulgaris

Question 7

Anti-dsDNA, anti-Smith

Answer 7

SLE

Question 8

Anti-glutamic acid decarboxylase (GAD-65)

Answer 8

Type 1 diabetes mellitus

Question 9

Antihemidesmosome

Answer 9

Bullous pemphigoid

Question 10

Anti-histone

Answer 10

Drug-induced lupus

Question 11

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 11

Polymyositis, dermatomyositis

Question 12

Antimicrosomal, antithyroglobulin

Answer 12

Hashimoto thyroiditis

Question 13

Antimitochondrial

Answer 13

1* biliary cirrhosis

Question 14

Antinuclear antibodies

Answer 14

SLE, nonspecific

Question 15

Antiparietal cell

Answer 15

Pernicious anemia

Question 16

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 16

Scleroderma (diffuse)

Question 17

Anti-smooth muscle

Answer 17

Autoimmune hepatitis

Question 18

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 18

Sjogren syndrome

Question 19

Anti-TSH receptor

Answer 19

Graves disease

Question 20

Anti-U1 RNP (ribonucleoprotein)

Answer 20

Mixed connective tissue disease

Question 21

IgA anti-endomysial, IgA anti-tissue tranglutaminase

Answer 21

Celiac disease

Question 22

MPO-ANCA/p-ANCA

Answer 22

Microscopic polyangiitis, eosinophiic granulomatosis with polyangiitis (Churg-Strauss sydrome)

Question 23

PR3-ANCA/c-ANCA

Answer 23

Granulomatosis with polyangiitis (Wegener)

Question 24

Rheumatoid factor (IgM antibody that targets IgG Fc region)

Answer 24

Rheumatoid arthritis

Question 25

Anti-CCP (more specific)

Answer 25

Rheumatoid arthritis