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Immunology - First Aid > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-postsynaptic ACh receptor associated disease?

A

Myasthenia gravis

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2
Q

Myasthenia gravis autoantibody?

A

Anti-postsynaptic ACh receptor

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3
Q

Anti-presynaptic voltage-gated calcium channel associated disease?

A

Lambert-Eaton myasthenic syndrome

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4
Q

Lambert-Eaton myasthenic syndrome autoantibody?

A

Anti-presynaptic voltage-gated calcium channel

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5
Q

Anti-β2 glycoprotein I associated disease?

A

Antiphospholipid syndrome

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6
Q

Antiphospholipid syndrome autoantibody?

A

Anti-β2 glycoprotein I

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7
Q

Antinuclear (ANA) associated disease?

A

Nonspecific screening antibody, often associated with SLE

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8
Q

Anticardiolipin, lupus anticoagulant associated disease?

A

SLE, antiphospholipid syndrome

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9
Q

Anti-dsDNA, anti-Smith associated disease?

A

SLE

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10
Q

SLE autoantibody?

A

Anti-dsDNA, anti-Smith

Anticardiolipin, lupus anticoagulant

Antinuclear (ANA)

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11
Q

Antihistone autoantibody associated disease?

A

Drug-induced lupus

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12
Q

Anti-U1 RNP (ribonucleoprotein) associated disease?

A

Mixed connective tissue disease

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13
Q

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific) associated disease?

A

Rheumatoid arthritis

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14
Q

Rheumatoid arthritis autoantibody?

A

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)

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15
Q

Anti-Ro/SSA, anti-La/SSB associated disease?

A

Sjögren syndrome

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16
Q

Sjögren syndrome autoantibody?

A

Anti-Ro/SSA, anti-La/SSB

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17
Q

Anti-Scl-70 (anti-DNA topoisomerase I) associated disease?

A

Scleroderma (diffuse)

18
Q

Anticentromere autoantibody associated disease?

A

Limited scleroderma (CREST syndrome)

19
Q

Antisynthetase (eg, anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2) autoantibody associated disease?

A

Polymyositis, dermatomyositis

20
Q

Associated disease with antimitochondrial autoantibody?

A

1° biliary cholangitis

21
Q

1° biliary cholangitis autoantibody?

A

Antimitochondrial

22
Q

Associated disease with anti-smooth muscle, anti-liver/kidney microsomal-1 autoantibody?

A

Autoimmune hepatitis

23
Q

Associated disease with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)/perinuclear ANCA (p-ANCA) autoantibody?

A

Microscopic polyangiitis

eosinophilic granulomatosis with polyangiitis

ulcerative colitis

1° sclerosing cholangitis

24
Q

Associated disease with PR3-ANCA/cytoplasmic ANCA (c-ANCA) autoantibody?

A

Granulomatosis with polyangiitis

25
Q

Associated disease with Anti-phospholipase A2 receptor autoantibody?

A

1° membranous nephropathy

26
Q

Associated disease with anti-hemidesmosome autoantibody?

A

Bullous pemphigoid

27
Q

Associated disease with anti-desmoglein (anti-desmosome) autoantibody?

A

Pemphigus vulgaris

28
Q

Associated disease with antithyroglobulin, antithyroid peroxidase/ antimicrosomal autoantibody?

A

Hashimoto thyroiditis

29
Q

Hashimoto thyroiditis autoantibody?

A

Antithyroglobulin, antithyroid peroxidase (antimicrosomal)

30
Q

Associated disease with anti-TSH receptor autoantibody?

A

Graves disease

31
Q

Graves disease autoantibody?

A

Anti-TSH receptor

32
Q

Associated disease with IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated
gliadin peptides?

A

Celiac disease

33
Q

Celiac disease autoantibody?

A

IgA anti-endomysial, IgA anti-tissue transglutaminase

IgA

IgG deamidated gliadin peptide

34
Q

Associated disease with anti-glutamic acid decarboxylase, islet cell Type 1 cytoplasmic antibody

A

Type 1 diabetes mellitus

35
Q

Type 1 diabetes mellitus autoantibody?

A

Anti-glutamic acid decarboxylase

Islet cell cytoplasmic antibodies

36
Q

Associated disease with antiparietal cell, anti-intrinsic factor autoantibody?

A

Pernicious anemia

37
Q

Pernicious anemia autoantibody?

A

Antiparietal cell

Anti-intrinsic factor

38
Q

Associated disease with anti-glomerular basement membrane autoantibody?

A

Goodpasture syndrome

39
Q

Goodpasture syndrome autoantibody?

A

Anti-glomerular basement membrane

40
Q

Bullous pemphigoid autoantibody?

A

Anti-hemidesmosome

41
Q

Pemphigus vulgaris autoantibody?

A

Anti-desmoglein (anti-desmosome)

Immunology - First Aid (15 decks)

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