Autoantibodies

Question 1

Anti-postsynaptic ACh receptor associated disease?

Answer 1

Myasthenia gravis

Question 2

Myasthenia gravis autoantibody?

Answer 2

Anti-postsynaptic ACh receptor

Question 3

Anti-presynaptic voltage-gated calcium channel associated disease?

Answer 3

Lambert-Eaton myasthenic syndrome

Question 4

Lambert-Eaton myasthenic syndrome autoantibody?

Answer 4

Anti-presynaptic voltage-gated calcium channel

Question 5

Anti-β2 glycoprotein I associated disease?

Answer 5

Antiphospholipid syndrome

Question 6

Antiphospholipid syndrome autoantibody?

Answer 6

Anti-β2 glycoprotein I

Question 7

Antinuclear (ANA) associated disease?

Answer 7

Nonspecific screening antibody, often associated with SLE

Question 8

Anticardiolipin, lupus anticoagulant associated disease?

Answer 8

SLE, antiphospholipid syndrome

Question 9

Anti-dsDNA, anti-Smith associated disease?

Answer 9

SLE

Question 10

SLE autoantibody?

Answer 10

Anti-dsDNA, anti-Smith

Anticardiolipin, lupus anticoagulant

Antinuclear (ANA)

Question 11

Antihistone autoantibody associated disease?

Answer 11

Drug-induced lupus

Question 12

Anti-U1 RNP (ribonucleoprotein) associated disease?

Answer 12

Mixed connective tissue disease

Question 13

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific) associated disease?

Answer 13

Rheumatoid arthritis

Question 14

Rheumatoid arthritis autoantibody?

Answer 14

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)

Question 15

Anti-Ro/SSA, anti-La/SSB associated disease?

Answer 15

Sjögren syndrome

Question 16

Sjögren syndrome autoantibody?

Answer 16

Anti-Ro/SSA, anti-La/SSB

Question 17

Anti-Scl-70 (anti-DNA topoisomerase I) associated disease?

Answer 17

Scleroderma (diffuse)

Question 18

Anticentromere autoantibody associated disease?

Answer 18

Limited scleroderma (CREST syndrome)

Question 19

Antisynthetase (eg, anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2) autoantibody associated disease?

Answer 19

Polymyositis, dermatomyositis

Question 20

Associated disease with antimitochondrial autoantibody?

Answer 20

1° biliary cholangitis

Question 21

1° biliary cholangitis autoantibody?

Answer 21

Antimitochondrial

Question 22

Associated disease with anti-smooth muscle, anti-liver/kidney microsomal-1 autoantibody?

Answer 22

Autoimmune hepatitis

Question 23

Associated disease with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)/perinuclear ANCA (p-ANCA) autoantibody?

Answer 23

Microscopic polyangiitis

eosinophilic granulomatosis with polyangiitis

ulcerative colitis

1° sclerosing cholangitis

Question 24

Associated disease with PR3-ANCA/cytoplasmic ANCA (c-ANCA) autoantibody?

Answer 24

Granulomatosis with polyangiitis

Question 25

Associated disease with Anti-phospholipase A2 receptor autoantibody?

Answer 25

1° membranous nephropathy

Question 26

Associated disease with anti-hemidesmosome autoantibody?

Answer 26

Bullous pemphigoid

Question 27

Associated disease with anti-desmoglein (anti-desmosome) autoantibody?

Answer 27

Pemphigus vulgaris

Question 28

Associated disease with antithyroglobulin, antithyroid peroxidase/ antimicrosomal autoantibody?

Answer 28

Hashimoto thyroiditis

Question 29

Hashimoto thyroiditis autoantibody?

Answer 29

Antithyroglobulin, antithyroid peroxidase (antimicrosomal)

Question 30

Associated disease with anti-TSH receptor autoantibody?

Answer 30

Graves disease

Question 31

Graves disease autoantibody?

Answer 31

Anti-TSH receptor

Question 32

Associated disease with IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptides?

Answer 32

Celiac disease

Question 33

Celiac disease autoantibody?

Answer 33

IgA anti-endomysial, IgA anti-tissue transglutaminase IgA IgG deamidated gliadin peptide

Question 34

Associated disease with anti-glutamic acid decarboxylase, islet cell Type 1 cytoplasmic antibody

Answer 34

Type 1 diabetes mellitus

Question 35

Type 1 diabetes mellitus autoantibody?

Answer 35

Anti-glutamic acid decarboxylase Islet cell cytoplasmic antibodies

Question 36

Associated disease with antiparietal cell, anti-intrinsic factor autoantibody?

Answer 36

Pernicious anemia

Question 37

Pernicious anemia autoantibody?

Answer 37

Antiparietal cell Anti-intrinsic factor

Question 38

Associated disease with anti-glomerular basement membrane autoantibody?

Answer 38

Goodpasture syndrome

Question 39

Goodpasture syndrome autoantibody?

Answer 39

Anti-glomerular basement membrane

Question 40

Bullous pemphigoid autoantibody?

Answer 40

Anti-hemidesmosome

Question 41

Pemphigus vulgaris autoantibody?

Answer 41

Anti-desmoglein (anti-desmosome)