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Immunology - First Aid > Adaptive Immunity > Flashcards

Adaptive Immunity Flashcards

1
Q

MHC are coded by which genes?

A

HLA genes

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2
Q

What is the function of MHC molecule?

A

Bind & present peptide Ag fragments (derived from pathogens) on the cell surface for recognition by the appropriate T cells

Bind T cell receptors (TCRs)

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3
Q

What are loci of MHC I?

A

HLA-A

HLA-B

HLA-C

(MHC I loci have 1 letter)

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4
Q

What are loci of MHC II?

A

HLA-DP

HLA-DQ

HLA-DR

(MHC II loci have 2 letters)

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5
Q

TCR & CD4 bind which major histocompatibility complex?

A

MHC II

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6
Q

MHC I bind to which receptors?

A

TCR & CD8

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7
Q

TCR & CD8 are specific for which MHC class?

A

MHC I

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8
Q

TCR & CD4 are specific for which MHC class?

A

MHC II

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9
Q

Where are MHC I expressed?

A

All nucleated cells

APCs

Platelets

(not on RBCs)

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10
Q

Where are MHC II expressed?

A

APCs

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11
Q

Which MHC class presents endogenously synthesized antigens (eg viral/ cytosolic proteins) to CD8+ cytotoxic T cells?

A

MHC I

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12
Q

MHC II present exogenously synthesized antigens (eg bacterial proteins) to which type of cells?

A

CD4+ helper T cells

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13
Q

Which MHC class presents exogenously synthesized antigens to CD4+ cytotoxic T cells?

A

MHC II

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14
Q

How is antigen loaded onto MHC I?

A

Antigen peptides loaded onto MHC I in RER (rough endoplasmic reticulum)

after delivery via TAP (transporter associated with Antigen processing)

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15
Q

In which MHC class is the antigen loaded following the release of invariant chain in an acidified endosome?

A

MHC II

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16
Q

How is antigen loaded onto MHC II?

A

Antigen loaded following release of invariant chain in an acidified endosome

17
Q

β-microglobulin is associated with which MHC class?

A

MHC I

18
Q

What is the associated protein of MHC II?

A

Invariant chain

19
Q

What is the associated protein of MHC I?

A

β-microglobulin

20
Q

Which HLA subtype associated with hemochromatosis?

A

A3

21
Q

HLA subtype A3 is associated with which disease?

A

Hemochromatosis

22
Q

Which HLA subtype associated with Addison disease, myasthenia gravis, Graves?

A

B8

23
Q

HLA subtype B8 is associated with which diseases?

A

Addison disease

myasthenia gravis

Graves

24
Q

Which HLA subtype associated with psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis?

A

B27

25
Q

HLA subtype B27 is associated with which diseases?

A

Psoriatic arthritis

Ankylosing spondylitis

IBD-associated arthritis

Reactive arthritis

(PAIR - seronegative arthropathies)

26
Q

Which HLA subtype associated with celiac disease?

A

DQ2/ DQ8

27
Q

Which disease is associated with HLA subtype DQ2/ DQ8?

A

Celiac disease

28
Q

HLA subtype DR43 is associated with which diseases?

A

DM type I

SLE

Graves

Hashimotos

Addison disease

29
Q

HLA subtype DR2 is associated with which diseases?

A

Multiple sclerosis

Hay fever

SLE

Goodpasture syndrome

30
Q

HLA subtype DR4 is associated with which diseases?

A

Rheumatoid arthritis

DM type I

Addison disease

31
Q

Which HLA subtype associated with Addison disease?

A

B8

DR3/ DR4

32
Q

Which HLA subtype associated with SLE?

A

DR2/ DR3

33
Q

Which HLA subtype associated with Graves disease?

A

B8

DR3

34
Q

Which HLA subtype associated with DM type I?

A

DR3/ DR4

35
Q

HLA subtype DR5 is associated with which diseases?

A

Pernicious anemia → vitamin B12 deficiency

Hashimoto thyroiditis

36
Q

Which HLA subtype associated with Hashimotos?

A

DR3

DR5

37
Q

Which HLA subtype associated with rheumatoid arthritis?

A

DR4

38
Q

What are the seronegative arthropathies?

A

PAIR

Psoriatic arthritis

Ankylosing spondylitis

IBD-associated arthritis

Reactive arthritis

Immunology - First Aid (15 decks)

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