Adaptive Immunity Flashcards
MHC are coded by which genes?
HLA genes
What is the function of MHC molecule?
Bind & present peptide Ag fragments (derived from pathogens) on the cell surface for recognition by the appropriate T cells
Bind T cell receptors (TCRs)
What are loci of MHC I?
HLA-A
HLA-B
HLA-C
(MHC I loci have 1 letter)
What are loci of MHC II?
HLA-DP
HLA-DQ
HLA-DR
(MHC II loci have 2 letters)
TCR & CD4 bind which major histocompatibility complex?
MHC II
MHC I bind to which receptors?
TCR & CD8
TCR & CD8 are specific for which MHC class?
MHC I
TCR & CD4 are specific for which MHC class?
MHC II
Where are MHC I expressed?
All nucleated cells
APCs
Platelets
(not on RBCs)
Where are MHC II expressed?
APCs
Which MHC class presents endogenously synthesized antigens (eg viral/ cytosolic proteins) to CD8+ cytotoxic T cells?
MHC I
MHC II present exogenously synthesized antigens (eg bacterial proteins) to which type of cells?
CD4+ helper T cells
Which MHC class presents exogenously synthesized antigens to CD4+ cytotoxic T cells?
MHC II
How is antigen loaded onto MHC I?
Antigen peptides loaded onto MHC I in RER (rough endoplasmic reticulum)
after delivery via TAP (transporter associated with Antigen processing)
In which MHC class is the antigen loaded following the release of invariant chain in an acidified endosome?
MHC II
How is antigen loaded onto MHC II?
Antigen loaded following release of invariant chain in an acidified endosome
β-microglobulin is associated with which MHC class?
MHC I
What is the associated protein of MHC II?
Invariant chain
What is the associated protein of MHC I?
β-microglobulin
Which HLA subtype associated with hemochromatosis?
A3
HLA subtype A3 is associated with which disease?
Hemochromatosis
Which HLA subtype associated with Addison disease, myasthenia gravis, Graves?
B8
HLA subtype B8 is associated with which diseases?
Addison disease
myasthenia gravis
Graves
Which HLA subtype associated with psoriatic arthritis, ankylosing spondylitis, IBD-associated arthritis, reactive arthritis?
B27
HLA subtype B27 is associated with which diseases?
Psoriatic arthritis
Ankylosing spondylitis
IBD-associated arthritis
Reactive arthritis
(PAIR - seronegative arthropathies)
Which HLA subtype associated with celiac disease?
DQ2/ DQ8
Which disease is associated with HLA subtype DQ2/ DQ8?
Celiac disease
HLA subtype DR43 is associated with which diseases?
DM type I
SLE
Graves
Hashimotos
Addison disease
HLA subtype DR2 is associated with which diseases?
Multiple sclerosis
Hay fever
SLE
Goodpasture syndrome
HLA subtype DR4 is associated with which diseases?
Rheumatoid arthritis
DM type I
Addison disease
Which HLA subtype associated with Addison disease?
B8
DR3/ DR4
Which HLA subtype associated with SLE?
DR2/ DR3
Which HLA subtype associated with Graves disease?
B8
DR3
Which HLA subtype associated with DM type I?
DR3/ DR4
HLA subtype DR5 is associated with which diseases?
Pernicious anemia → vitamin B12 deficiency
Hashimoto thyroiditis
Which HLA subtype associated with Hashimotos?
DR3
DR5
Which HLA subtype associated with rheumatoid arthritis?
DR4
What are the seronegative arthropathies?
PAIR
Psoriatic arthritis
Ankylosing spondylitis
IBD-associated arthritis
Reactive arthritis
