Auto-Injectors, Pens + Pre-filled Syringes Flashcards

1
Q

Why these devices?

A

Improved safety
Improved dosing accuracy
Patient compliance

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2
Q

What are the different types?

A

Vial
Cartridge
Disposable pen

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3
Q

What are the different classifications?

A

Single use
Disposable = used until empty
Reusable = new drug can be loaded into container

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4
Q

What is a vial?

A

Closed vessel containing insulin, which is sealed with pressurised seal

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5
Q

What are the positives of a vial?

A

Can use for multiple patients
Larger size
Good in secondary care/healthcare/nursing home
Can be used to fill insulin pumps

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6
Q

What are the negatives of a vial?

A

Require syringe to give dose
Measuring dose potentially more difficult as syringe needed
Not all insulins available in a vial

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7
Q

What is a cartridge?

A

Disposable container of insulin which is inserted into non-disposable pen device

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8
Q

What are the positives of a cartridge?

A

Used in non-disposable pen = preferrable
Easy to dial up dose

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9
Q

What are the negatives of a cartridge?

A

May not be preferrable = non-disposable pen
Pen breaks = no alternative to give insulin
Not all insulins available as cartridge

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10
Q

What is a pre-filled pen?

A

Disposable container of insulin in a pen, which is fully enclosed + disposed of when finished

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11
Q

What are the positives of a pre-filled pen?

A

Breaks can easily replace
Easy to dial up dose
Can be recycled

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12
Q

What are the negatives of pre-filled pen?

A

Differences between disposable pens
Not all insulins available in pre-filled pens

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13
Q

What is an insulin pump?

A

Continuous subcutaneous insulin infusion

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14
Q

What are the positives of an insulin pump?

A

Mirrors body + natural pancreatic function
Can be used as closed loop with monitoring devices
Only need one type of insulin
Deliver basal + bolus doses
Different types of pumps available for patient need

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15
Q

What are the negatives of an insulin pump?

A

Requires high level of patient input
Need good dexterity to fill + use
Pump fails = DKA develop fast
Higher risk of DKA

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16
Q

Describe dose of pre-filled syringes

A

Single dose = fixed

17
Q

Describe autoinjector design

A

Self-firing mechanism

18
Q

What are the considerations of autoinjector?

A

Needle length - IM/SC
Method of administration - “place + press”/”swing + jab”
Good in an emergency

19
Q

What is the length for IM?

A

7/8mm

20
Q

What is the length for SC?

A

<6mm

21
Q

What is an autoinjector?

A

Self-firing mechanism for delivery of insulin

22
Q

What are the positives of an autoinjector?

A

Improved accuracy of dosing
Designed for people with no medical expertise
Good in an emergency
Reduced risk of needle stick injury
Overcomes needle phobia
Reduce healthcare time input

23
Q

What are the negatives for autoinjectors?

A

Futuristic = NOT yet used in practice for insulin

24
Q

What is syringeability?

A

Force required to inject a given solution at a given rate via a chosen needle length + gauge

25
Q

What is the standard needle length for SC (insulin)?

A

4mm

26
Q

What does a longer needle increase the risk of?

A

IM injection

27
Q

Describe siliconization interaction

A

Barrier between glass + drug formulation
Prevents adsorption to glass surface
Improved drainability
Lubricates syringe barrel

28
Q

What are the syringe materials?

A

Glass = excellent barrier properties, inert
Plastic = stability + environmental issues

29
Q

What are the gold standard container closure?

A

Elastomeric closures

30
Q

Why are elastomeric closures good?

A

Preserve contents
Do not interact with contents
Physical functionality
Leakproof
Safety for end user