Auto Immune Hemolytic Anemia

Question 1

Obj.1: List 4 causes of a positive DAT, and for each:

Answer 1

1. Hemolytic Transfusion Reactions
2. Hemolytic Disease of the Newborn
3. Autoimmune Hemolytic Anemias (Warm & Cold)
4. Drugs

Question 2

Obj. 1: For each cause of a positive DAT:
- Hemolytic Transfusion Reactions
a. Classify as alloimmune or autoimmune
b. Describe the DAT appearance

Answer 2

a. Alloimmune
b. Recipient antibody attaches to transfused donor cells with corresponding
antigen

Question 3

Obj. 1: For each cause of a positive DAT:
- Hemolytic Disease of the Newborn
a. Classify as alloimmune or autoimmune
b. Describe the DAT appearance

Answer 3

a. Alloimmune
b. Mother’s IgG antibody crosses placenta and attaches to the baby’s paternally derived antigens