Auto Antibodies Flashcards
1
Q
Anti mitochondrial (AMA) -98%
A
Primary Biliary Cirrhosis (Intrahepatic ducts destroyed by granulomas) Pruritis and pigmentation (face) Bones (osteoporosis) and big organs (HSM) Cirrhosis and coagulopathy (low Vit K) Hypercholesterolaemia Mx: Symptomatic (pruritis - cholestryamine) Specific (ADEK, ursodeoxycholic acid) Liver tx
2
Q
Anti Centromere
A
Limited sclerosis (CREST)
3
Q
Anti Jo/Mi2
A
Polymyositis
4
Q
Anti Scl70
A
Diffuse sclerosis
5
Q
Anti La
A
Sjorgrens
6
Q
ANA +/or SMA
A
Type I AI hepatitis
7
Q
Anti liver-kidney microsomal type 1 (LKM1)
A
Type II AI Hepatitis
8
Q
Anti GM1
A
Guillain Barre (25%)
Immune mediated demyelination (ascending weakness/paralysis)
Mx supportive and immunosuppression (IVIg and Pex)
9
Q
Anti Ro
A
Sjorgrens and heart block
10
Q
Anti GBM
A
Good pastures syndrome
Rapidly progressive GN
(Haematuria and haemoptysis, mx plasmapheresis and immunosuppression)
11
Q
cANCA
A
Wegners
12
Q
pANCA
A
Churg Strauss and microscopic polyangiitis
13
Q
Anti Histone
A
Drug induced SLE
14
Q
Gastric parietal cell
A
Pernicious anaemia
15
Q
Anti VGCC (voltage gated calcium channel)
A
Lambert Eaton
