Autism Spectrum Disorder Flashcards
What is autism spectrum disorder?
A neurodevelopmental condition characterised by:
- Qualitative impairment in social interaction and communication
- Repetitive stereotyped behaviour
- Repetitive stereotyped interests
- Repetitive stereotyped activities
What is the prevelance of ASD?
1-2%
Around 50% have an intellectual disability
Which sex is ASD more common in?
3-4x more common in boys than girls
When do the typical symptoms of ASD usually present?
Between 2-3 years of age (early manifestations) or may manifest later
How can the clinical features of ASD be classified?
- Impaired social communication and interaction
- Repetitive behaviours, interests and activities
- Often associated with intellectual impairment or language impairment
- ADHD (35%), epilepsy (18%)
- Higher head circumference to brain volume ratio
What are examples of impaired social communication and interaction in ASD?
- Children frequently play alone and may be relatively uninterested in being with other children
- Failure to regulate social interaction with nonverbal cues like eye gaze, facial expression and gestures
- Fail to form and maintain appropriate relationships and become socially isolated
- Speech and language delay, monotonous tones of voice with limited expression and difficulty using pronouns
What are examples of repetitive behaviours, interests and activities?
- Stereotyped and repetitive motor mannerisms, inflexible adherence to nonfunctional routines or rituals
- Children are noted to have particular ways of going about everyday activities
How is the treatment of ASD classified?
- Educational and behavioural management
- Medical therapy
- Family counselling
What is the goal of ASD treatment?
To increase functional independence and QOL:
- Learning and development, improved social skills and improved communication
- Decreased diability and comorbidity
- Aid to families
Always a multidisciplinary approach
What are the patient non-pharmacological therapies?
- Applied behavioural analysis
- ASD preschool program
- Treatment and education of autistic and communication related handicapped children (TEACHH)/ structured teaching method
- Early start denver model (ESDM)
- Joint attention symbolic play engagement and regulation (JASPER)
What are the patient pharmacological therapies?
- SSRIs
- Antipsychotics
- Methylphenidate
What is the use of SSRIs in ASD management?
Reduce symptoms like repetitive stereotypes behaviour, anxiety and aggression
What is the use of antipsychotics in ASD management?
Reduce the symptoms of aggression, self-injury
What is the use of methylphenidate in ASD?
Reduces ADHD symptoms
What should pharmacological management not be used for in autism?
To treat the core features of autism