Autcoids Flashcards
Highly sedative anti histaminics
PRO METHA ZINE,
DI PHEN HYDRA MINE,
HYDROXY ZINE,
DOXE PIN,
DOXYL AMINE
Anti histaminic with transdermal patch
Diphenhydramine
Anti histaminics ,used in
Motion sickness,
Drug induced parkinson’s disease
Pronethazine,
Diphenhydramine
Anti histaminics which can also be used as local anaesthetic
Promethazine,
Diphenhydramine
Anti histaminics with maximum anti pruritic effect
Hydroxyzine
Anti histaminic which is also a tricyclic antidepressants
Doxepin
Antihistamine
DOC in morning sickness
Doxylamine
Moderately sedative antihistamine
Cycli zine,
Mecli zine,
Cinnari zine,
Cypro heptadine,
Pheni ramine
Antihistamine good in sea sickness
Cycli zine,
Mecli zine,
Cinnari zine
Antihistamine + anti serotonin
Cypro heptadine
Least sedative antihistamine
CHLOR pheni ramine,
Clemastine,
Tirolidine
DOC in Anaphylaxis
I/m adrenaline 0.5 ml of 1:1000
2nd gen antihistamine
Fexo fenadine,
Cetrizine,
Levo cetrizine,
Loratidine,
Rupatidine,
Banned 2nd gen antihistamine
Terfinadine,
Astemizole
2nd gen antihistamine also PAF inhibitor
Rupatidine
Topical 2nd gen antihistamine
ALOKA
A- Aze lastine
L- levo car bastine
O- Olopa tidine
K- Keto tifen
A- Alcaf tadine
H2 blockers
Cime tidine,
Rani tidine,
Famo tidine,
Roxa tidine,
Niza tidine,
Lafu tidine,
H2 blockers which causes
Gynecomastia,
Menstrual irregulation
Cime tidine
H2 blockers which can cause
Galactorrhoea
Cime tidine
H2 blockers - max. CYP inhibitor
Cime tidine
Only drug for H3 receptor
Tipro lisant (pito lisant)
H3 INVERSE ANTAGONIST
INC. HISTAMINIC RELEASE
Tipro lisant can be used to treat
Narcolepsy
DOC in narcolepsy
Moda finil
No. Of receptors of serotonin
7,
5HT1-5HT7
Only ionotropic receptor of serotonin
5HT3
5HT1-ttpe and location
Gi,
Brain
Subtypes of 5Ht1 receptor
5HT1A,B,D,F
5HT1A partial agonist
Buspirone
Specific 5ht1B/D agonist
Triptans
DOC in acute attack of migraine
Triptans
Name some Triptans
SER FANZ (all ends with Triptan)
S- Sunatriptan
E- Eletriptan
R- Rizatriptan
F-Frovatriptan
A-Almotriptan
N- Naratriptan
Z- Zolmitriptan
Triptan which can be given by all routes iv,im, rectal, transdermal and nasal spray
Sunatriptan
Most effective Triptan
Eletriptan
Fastest acting Triptan
Rizatriptan
2nd most effective Triptan
Rizatriptan
Longest acting Triptan
Frovatriptan
Triptan with best oral absorption
Naratriptan
Triptan which can be given as nasal spray
Zolmitriptan
Non specific 5HT1 agonist
Ergotamine
Triptan/ergotamine,
Emetogenic/ anti emetic
Triptan -anti emetic
Ergotamine - emetogenic
Side effects of Triptan, ergotamine
HERD
H- Hypertension, coronary vasospasm
E- erythromelalgia
R- raynauds disease
D- dry gangrene of fingers
Triptan, ergotamine are C/I in
CAD(coronary artery disease) patients -can cause MI and angina
Treatment of ergotism
Nitroprusside - vasodilator
DOC for prolactinoma
Cabergoline
DOC in prolactinoma+ pregnancy
Bromocriptine - dopamine agonist
Which ergots cause cardiac valvular fibrosis
Pergolide,
Cabergoline
Ergots which causes retroperitoneal fibrosis
Methysergide
Inflammatory fibrosis by ergots
Cardiac valvular fibrosis,
Retroperitoneal fibrosis,
Pleural fibrosis,
Peritoneal fibrosis
T/t of mild migraine
NSAIDS along with caffeine
PAIND
P- PCM
A- Aspirin
I- Indomethacin
N- Naproxen
D- Diclofenac
T/t Moderate/severe migraine
Triptan» ergotamine
Migraine+ Triptan resistant+ heart patient —drug preferred
Opioids like
Butorphanol,
Pethidine,
Morphine
Drugs to control migraine aura
D2 antagonist like
Domperidone,
Metoclopramide,
Antipsychotic like
Chlorpromazine,
Prochlorperazine
T/t migraine in pregnancy
Safest drug PCM
