Audition Flashcards

1
Q

Wavelength

A
  • distance from start of one cycle to another (meters/cycle)

- Wavelength = c/ frequency (C= speed in medium)

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2
Q

Frequency

A
  • # cycle per second or hertz (1/period); determines pitch we hear
  • 20-20,000 Hz range in humans
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3
Q

Amplitude

A
  • proportional to amount of pressure; conveys loudness

- Sound Pressure Level = 20 log (P/Pref) in decibels

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4
Q

Outer Ear (structures & function)

A
  • Outer - pinna/auricle, concha, external meatus, tympanic membrane
  • Goal = funnel sound
    • Band pass filter - certain frequency bands better than others
    • Resonance chamber - summation of sound waves for gain/amplification
    • Help w/ localization of sound b/c amount of shadowing by head and pinna tells about source
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5
Q

Middle Ear (structures & function)

A
  • air filled space w/ ossicles
  • Malleus - incus - stapes which inserts onto oval window
  • Vibrate to inc sound pressure
  • Movement controlled by tensor tympani & stapedius which contract to stiffen bones and dec their enhancing effect (protective)
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6
Q

Inner Ear (structures & function)

A
  • cochlea; fluid-filled chamber w/in temporal bone
  • Coil of 3 tubes (scala vestibuli, scala media, scala tympani)
    - Vestibuli & tympani are connected and filled w/ perilymph (high Na+ low K+)
    - Media contained endolymph (low Na+ high K+)
    -
    Organ of Corti - rest on basilar membrane; signal transduction
    • 1 row inner hair cells; 3 rows outer hair cells
  • Vibration to oval window —> scala vestibule wave —> deflection of Corti & basilar membrane —> shearing of hair cells stereo cilia
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7
Q

How is the cochlear duct organized?

A
  • High frequency peaks first - near basal end

- Low frequency peaks later - near apical end

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8
Q

Type I v Type II Axons

A
  • Type I - thick, myelinated; afferents mainly from inner hair cells; 1 nerve per inner hair cell but 1 hair cell can connect to multiple nerves
  • Type II - thin, un-myelinated; efferents mainly to outer hair cells; multiple outer hair cells innervated by 1 efferent
    • Cell bodies from superior olive —> release acetylcholine —> hyper polarization of outer hair cells —> dec cochlear sensitivity & cochlear amp
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9
Q

Central Auditory Path (CN 8 on)

A
  • CN 8 —> bifurcates —> ipsilateral dorsal and ventral cochlear nuclei (brainstem) —> MSO & LSO (superior olivary complex) —> lateral lemniscus —> inferior colliculus (processing)—> medial geniculate nucleus —> auditory cortex
    • Cochlear nuclei are mono-aural (one ear) then all else integrate both ears
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10
Q

Central Auditory Organization

A
  • Ea 8th nerve axon has characteristic frequency —> tonotopic mapping in 8th nerve
  • Firing rate tells about amplitude or loudness (greater rate = greater amp)
  • Primary auditory cortex is organized tonotopically - columnar organization w/ ea column havig characteristic frequency
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11
Q

How is sound localized?

A
  • MSO - medial superior olivary nucleus - interaural time differences
    - Excitation from both ipsilateral & contralateral ear
  • LSO - lateral superior olivary nucleus - interaural intensity differences
    - Excitation from ipsilateral ear; inhibition from contralateral ear (glycine)
    - Contralateral delay overcome by highly efficient Calyces of Held
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12
Q

Conductive Hearing Loss

A
  • Sound fails to reach inner ear
  • Negative Rinne (bone&raquo_space; air conductance)
  • Usually mono-aural
  • Causes - OM (ossicles affected by scar tissue), otosclerosis (proliferation of ossicles)
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13
Q

Sensorineural Hearing Loss

A
  • Sound fails due to loss of hair cells or 8th nerve fibers
  • Positive Rinne (air still&raquo_space; bone conductance but both low)
  • Usually mono-aural
  • Causes - ototoxic agents, infection, acoustic trauma, aging
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14
Q

Central Hearing Loss

A
  • Usually bi-aural b/c loss of central pathways (unless loss of cochlear nuclei)
  • Causes - tumor, stroke
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15
Q

Tinnitus

A
  • objective or subjective (only heard by pt)
    • May be due to acoustic trauma or meds
    • Tx - hearing aids, cochlear implants, cognitive therapy, Xanax, anti-dep, anti-convulsants, anti-histamines, lidocaine
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16
Q

What drugs can affect hearing?

A
  • Loop diuretics - block Na/K/Cl channels —> breakdown of endocochlear potential
  • Aminoglycosides (gentamycin, tobramyocin, etc) - enter hair cells via same mechxnosensitive channels as K+ then can cause hair cell death
17
Q

OAEs & AEPs

A
  • OAEs - otoacoustic emissions- test cochlea to see if it’s producing sound via basilar membrane
  • AEPs - test central auditory pathways by recording from brain (8th nerve, brainstem or cortex problem)