Attrition and Data Handeling

Question 1

Identify where in the methods data handling is described

Answer 1

-look at the SUPPLEMENT
-statistical analysis

Question 2

define attritation

Answer 2

-the action or process of gradually REDUCING the strength or effectiveness of someone/something
-loss of participants from a randomized control trial

Question 3

effects of attritation

Answer 3

-introduction of bias
-impact on trial results
-benefits of randomization are lost
-no specific level where it becomes a problem

Question 4

Key questions for attrition

Answer 4

-Are the reasons for incomplete/missing data adequatly explained?
-Do the authors’ attempt to address attrition in analysis

Question 5

reporting attrition

Answer 5

-standard: include table with baseline characteristics of trial participants
-Ideal: present baseline and those lost seperatly

Question 6

true or false: ITT increases internal validity and PP does not

Answer 6

False. both decrease internal validity

Question 7

Intention to treat (ITT)

Answer 7

-analyzed as randomized
-conservative estimates in the difference between treatments (less favorable to intervention)
-preserves sample size which has more statistical power

Question 8

per protocol analysis

Answer 8

-as treated
-analyze only study participants who complete the full study
-benefits of randomization are lost
-more generous estimate between treatments

Question 9

True or false: for noninferiority trials, both ITT and PP analyses should be presented

Answer 9

true