ATN Flashcards
1
Q
What is the most common renal cause of ARF?
A
ATN
2
Q
What changes occur in ATN?
A
Tubular epithelium dies first during ischaemia
Epithelial cells degenerate and detach from tubular BM
GFR falls
3
Q
Is ATN reversible?
A
Yes, with dialysis
4
Q
What is one of the hallmarks of recovery in ATN?
A
Diuresis
5
Q
What histological characteristics are seen in ATN?
A
Granular eosinophilic trails of debris due to sloughing of dead tubule cells
Glomeruli normal
6
Q
When does hypoperfusion cause ATN?
A
Only when severe and protracted enough to cause necrosis of tubular epithelium (GFR fall in hypoperfusion is initially due to low perfusion, not tubule cell necrosis)
7
Q
Give examples of some causes of toxic ATN
A
Heavy metals, e.g. mercury
Some antibiotics
Some chemotherapeutics
