Atieology, Pathogenesis, Pathophysiology Flashcards

1
Q

Disease is a state of—-

A

Alterations in the body

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2
Q

Disease is a dynamic process which on set may be?

A

Acute or chronic
Duration is variable
Result in recovery(partially or fully) or lead to death

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3
Q

Division of aetiology

A

Intrinsic
Acquired(physical, chemical or exposure to microbiologic agents

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4
Q

Majority of diseases have simple aetiology. T/F

A

False. Complex

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5
Q

Diseases have complex aetiology so they are referred to as?

A

Multi factorial

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6
Q

Pathophysiology refers to the —— associated with or resulting from diseases or injury and the ——

A

Functional changes
Scientific study of such changes

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7
Q

Diseases are better understood from the perspective of?

A

Disordered physiology(pathophysiology)

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8
Q

Pathophysiology can also be referred to as —— concerned with —-

A

Physiopathology
Bodily functional change that causes a disease or bodily functional change that result from disease

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9
Q

Pathophysiology is concerned with 3 things what are they?

A

The alteration
The mechanism of disruption
How they manifest as symptoms and signs as well as laboratory findings

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10
Q

Pathophysiology provides the link between what and what?

A

Basic science and clinical practice

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11
Q

While PP studies all structural, biochemical, functional changes in cells, tissues, organs in disease state. PP does all with the exclusion of —

A

Structural changes

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12
Q

What is pathogenesis?

A

It deals with the sequence of events in response of cells and tissues to etiological agents from the initial stimulus to the ultimate expression of the disease

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13
Q

A major pillar of pathology involving the biochemical and morphological changes that occur before a disease is manifested is called?

A

Pathogenesis

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14
Q

Concept of normalcy is said to be — to an extent

A

Arbitrary

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15
Q

Concept of normalcy is influenced by?

A

Cultural values
Biological realities

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16
Q

Normal value for CON is measured by?

A

An average value for that parameter

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17
Q

What age reasons for variations?

A

Diff genetic composition
Diff life styles and environment
Physiological process vary

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18
Q

Maintenance of internal constancy is a less essential feature of normalcy. T/F?

A

False

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19
Q

Requirements for cells to maintain normalcy?

A

Oxygen and nutrients
An environment with narrow ranges of PH, temperature, water and salt

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20
Q

What are the 4 aspects of disease process?

A

Aetiology
Pathogenesis
Molecular and morphological changes
Clinical manifestations

21
Q

Disease is not a new form of life but an —— or —— of new life processes

A

Extension or distortion

22
Q

What is Health according to WHO?

A

It is the state of complete physical, social and mental wellbeing and not merely the absence of disease and infirmity

23
Q

Stages of disease manifestation

A

Subclinical Latent(incubation)
Clinical manifestation
Recovery or complications

24
Q

Abnormality of a disease can be detected by what?

A

Laboratory tests-incubation period e.g in Hepatitis

25
Q

Many organs in the body have large reserve A.K.A?

A

Safety margin

26
Q

When there is an encroachment on normal biological processes the manifestations are often —— which may be ——

A

Subjective, non-specific

27
Q

What are the two types of symptoms

A

Objective and subjective

28
Q

Dyspepsia in gastric cancer is also know as?
What kind of symptom is it?

A

Indigestion
Subjective

29
Q

A demonstrable structural change produced in the course of a disease which may be microscopic or macroscopic is called?

A

Lesion

30
Q

Disease are static not dynamic

A

False

31
Q

Every disease has a range of manifestation or natural history. T/F?

A

True

32
Q

Manifestations of disease is determined by?

A

Shift in biological equilibrium as compensatory mechanisms come in

Environmental influences on the patient

33
Q

Most causes of diseases are acquired from environments. Some of those causes include?

A

Infection
Mechanical trauma
Toxic substance
Radiation
Nutritional Aberration

34
Q

Most causes of diseases are acquired from environment. What are some of these causes?

A

Infection
Mechanical trauma
Radiology
Nutritional aberration
Toxic substances

35
Q

Characteristics of host that influence diseases are?

A

Age
Gender
Past medical history

36
Q

What determines the Pathogenesis of a disease?

A

Genetic constitution

37
Q

Genetic constitution is almost always important in most diseases because it determines?

A

Anatomical characteristic
Physiological mechanisms
Mode of response to injury

38
Q

In infectious disease which is exogenous genetic factors can influence the susceptibility to the infectious agent. T/F?

A

True

39
Q

Hereditary, environment and host

A

All three are factors that affect diseases

40
Q

Example of a disease determined largely by genetic errors and expressed regardless of extrinsic influences includes?

A

Sickle cell

41
Q

Diseases between genetic and extrinsic factors include?

A

Cancer

42
Q

What is H. Pylori?

A

It is a spiral, microaerophilic gram negative bacterium

43
Q

H.Pyloric Gastric disease is transmitted via

A

Oral-oral
Faeco-oral route

44
Q

H.pyloric causes multiple diseases in the lower GIT. T/F

A

False

45
Q

Pathogenesis is an interplay of?

A

The bacterial factors
The host responses
Modulating co-factors such as diet and cigarettes smoking

46
Q

Cancer is a complex disorder caused by multiple factors combined. T/F?

A

True

47
Q

Is breast cancer or retinoblastoma a Hereditary or acquired cancer?

A

Hereditary

48
Q

Acquired factors are non-modifiable. T/F

A

False

49
Q

One third of cancer deaths in Africa are due to?

A

Diet
Tobacco
Infection