Adaptations Of Cellular Growth Flashcards
Adaptations are?
A cells response to changes in its environment
Cells response may change in?
Number, size, phenotype, metabolism
Types of adaptation?
Hyperplasia
Hypertrophy
Metaplasia
Atrophy
Hypertrophy is increase in cell which leads to ——
Increase in the size of the organ
Hypertrophy is seen in cells which cannot undergo division only. T/Ff
False
Hypertrophy occurs as a result of?
Synthesis of increased structural elements in the cell
Hypertrophy can be —— or ——
Pathologic and physiologic
Physiologic Hypertrophy results from?
Increased stimulation of cells by hormones or increased functional demand
The combined actions of mechanical sensors, vasoactive agents and growth factors lead to generation of ——which are transmitted into the cell through ——
Signal, signal transduction pathway’s
Other adaptive changes that occur in Hypertrophy is change from Alpha to Beta isoform of myosin heavy chain, in creased expression of ANF gene in states of cardiac Hypertrophy. T/F
True
What are some physiological Hypertrophy characteristics?
Normal cardiac function
Normal gene expression
No fibrosis
Proportional chamber enlargement
What are some pathological Hypertrophy characteristics?
Cardiac dysfunction
Fibrosis
Myocyte necrosis and apoptosis
Associated with heart failure and increased mortality
Hyperplasia
Increase in number of cells in an organ
May occur together with Hypertrophy under what condition?
Cell is capable of dividing
Physiologic hyperplasia is divided into?
Functional and compensatory
