Atchley's Lectures Flashcards
1
Q
is HIV curable?
A
NO
- no cure, but treatable
- start ART when diagnosed (same day) if no opportunistic infection
2
Q
Idiopathic CD4+ Lymphocytopenia (ICL)
A
low CD4+ (<300), but HIV neg
3
Q
retroviruses carry what enzyme?
A
reverse transcriptase
- RNA -> DNA
- RNA dependent DNA polymerase
4
Q
both HTLV-1 and HTLV-2 need what before transfusion?
A
blood screen
- if +, cannot give blood
- BLURRED presentation w/ HTLV-1
5
Q
what virus has reverse transcriptase but is NOT a retrovirus?
A
HBV***
6
Q
which HIV virus is unresponsive to NNRTI?
A
HIV-2
7
Q
POL gene
A
make reverse transcriptase, protease, integrates
- target for drugs
- mutated POL -> resistance
8
Q
4th generation ELISA
A
- diagnostic test for HIV
- p24 antigen and HIV Abs
- if + have to do HIV-1,2 differentiation w/ immunoblot assay
9
Q
env gene
A
makes the GP surface proteins
- Gp160 -> mother
- Gp 41 -> fusion and penetration
- Gp120 -> attachment/binding
10
Q
T troph (X4) viruses
A
- target CXCR4 receptors (ALL T cells)
- LATE stage
- deplete all T cells
11
Q
M troph (R5) viruses
A
- target CCR5 receptors (Macs/Monocytes/15-30% T cells)
- EARLY stage
- hide from immune surveillance
12
Q
which viruses are the TRANSMITTING viruses?
A
R5 viruses
-CCR5 mutations -> decreased susceptibility to HIV
13
Q
AIDS
A
-HIV+ PLUS CD4 <200 or an AIDS defining illness
14
Q
Kaposi Sarcoma
A
- HHV-8
- LYMPHOCYTE infiltrate
15
Q
Bacillary Angiomatosis
A
- Bartonella Hens.
- NEURTROPHIL infiltrate
