Asthma_Lect 10

Question 1

Is asthma associated with obstructive or restrictive pathophysiology?

Answer 1

Asthma is a chronic inflammatory disorder characterized by airway OBSTRUCTION, clinical symptoms, and airway hyperresponsiveness

Question 2

During allergic sensitization: Naive T triggers Th2 which activates____ which produces _____ that is involved directly in reexposure?

Answer 2

Th2 cells which interact with the MHC Class II epitope. The B cells are activated which produces Mast Cells that are specific for the allergic antigen.

Question 3

What are the time courses of inflammatory mediator release?

Answer 3

Immediate (Granule Contents) - histamine, tnf-alpha,protease, heparin

Minutes (Lipid): prostaglandin, leukotriene

Hours (Cytokines): IL-4/13

Question 4

Step 6 of NAEPP guidelines says to treat with?

Answer 4

Oral Corticosteroids

Question 5

Which type of Alveolar ventilation is an issue in asthma?

Answer 5

Hyper AND Hypo Ventilation.

Hyperventilation initially followed by hypoventilation later due to muscle fatigue