Asthma (Newman) Flashcards
Curschmann spirals
characteristic finding in sputum or broncho-alveolar lavage specimens
extrusion of mucus plugs from sub-epithelial mucous gland ducts or bronchioles
Charcot-leyden crystals
found in sputum or broncho-alveolar lavage specimens
composed of an eosinophil protein called galectin-10
what happens to the sub-basement membrane in asthma
fibrosis due to type 1 and 3 collagen
submucosal glands in asthma
increase in size and the number of goblet cells increase
bronchial wall muscle in asthma
hypertrophy and hyperplastic
airway remodeling may contribute to
chronic irreversible airway obstruction
exampe of inhaled allergens
atopic allergens including
dust mites
cockroaches
seasonal pollens
atopy is the ___ in asthma
strongest predisposing factor
nonspecific precipitants (triggers)
exercise URI sinusitis allergic rhinitis aspiration GER air pollution meds (aspirin/NSAID) occupation obesity
is chronic progressive cough common in asthma
not common
do you commonly wake at night with breathlessness or wheezing with COPD
not commonly
do the symptoms of COPD exhibit day to day variability
no
with drug therapy would you expect FEV and FEV/FVC ratios to return to normal
never with significant disease but probably will with asthma
key indicators of asthma
wheezing (esp in kids)
history of cough or recurrent wheeze, difficulty in breathing, and chest tightness
symptoms occur/worsen with exercise, viral infection, change in weather, strong emotion, menstrual cycle, or allergens
key indicators of COPD
dyspnea that is progressive, worsens with exercise, persistent, or described by pt as increased effort to breathe, heaviness, air hunger, or gasping
chronic cough that may be intermittent or unproductive
chronic sputum production
history of exposure to risk factors especially tobacco smoke, occupational dust, and chemicals or smoke from home cooking and heating fuels
be sure you check out the flow diagram for vocal cord dysfunction
the inspiration below the x axis is truncated
ICS we should know
fluticasone
beclomethasone
budesonide
leukotriene modifiers we should know
montelukast
zafirlukast
5-lipoxygenase inhibitor we should know
zileuton
it inhibits leukotriene formation
Respiratory arrest imminent, breathlessness
white at rest, mute