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Therapeutics > Asthma/ COPD Medications and Staging > Flashcards

Asthma/ COPD Medications and Staging Flashcards

1
Q

Beclomethasone Brand Name

A

QVAR

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2
Q

Beclomethasone dosage form

A

Redihaler (MDI)

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3
Q

Beclomethasone class

A

Inhaled corticosteroids (ICS)

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4
Q

Beclomethasone age groups

A

5-11; adults

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5
Q

Budesonide brand

A

Pulmicort

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6
Q

Budesonide dosage form

A

Flexhaler (DPI) and Respules (nebulizer solution)

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7
Q

Budesonide class

A

ICS

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8
Q

Budesonide age groups

A

Flexhaler: 5-11; adults
Nebulizer: 0-4, 5-11

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9
Q

Budesonide counseling notes

A

Respules should be used with jet nebulizer and should not be mixed with other solutions

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10
Q

ciclesonide brand

A

Alvesco

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11
Q

ciclesonide dosage form

A

HFA; MDI

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12
Q

ciclesonide class

A

ICS

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13
Q

ciclesonide age groups

A

6-adult

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14
Q

Fluticasone propionate brand

A

Flovent, ArmonAir

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15
Q

fluticasone propionate dosage form

A

HFA (MDI), DPI, Aerosol Powder Inhaler (Digihaler)

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16
Q

fluticasone propionate age groups

A

Flovent- 4-adult
Armon Air Digihaler- adults only

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17
Q

fluticasone propionate class

A

ICS

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18
Q

fluticasone furoate brand

A

arnuity ellipta

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19
Q

fluticasone furoate dosage form

A

ellipta (DPI)

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20
Q

fluticasone furoate age groups

A

5-11; adult

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21
Q

mometasone brand name

A

Asmanex

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22
Q

mometasone dosage form

A

HFA (MDI), Twisthaler (DPI)

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23
Q

mometasone age groups

A

4-11; adults

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24
Q

what disease states can ICS be used for

A

asthma, copd

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25
Q

do intermittent asthma patients need ics?

A

no

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26
Q

ICS adverse effects

A

oral thrush, cough, dysphonia (difficulty speaking)

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27
Q

ICS counseling tips

A

patients should rinse mouth to prevent thrush, most effective long-term control therapy for asthma, may increase pneumonia risk in COPD patients (immune suppression), use lowest effective dose (high dose increases risk for systemic side effects).

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28
Q

LABA MOA

A

increase cAMP, relaxes bronchial smooth muscle and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)

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29
Q

ICS MOA

A

immune suppression; prevent and control inflammation

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30
Q

Arformoterol tartrate brand

A

Brovana

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31
Q

arformoterol tartrate dosage form

A

nebulizer solution

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32
Q

arformoterol tartrate age groups/indication

A

adult; copd only

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33
Q

formoterol brand name

A

Perforomist

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34
Q

formoterol dosage form

A

nebulizer solution

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35
Q

formoterol age groups/ indication

A

adult only; COPD only unless used with ICS

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36
Q

indacaterol brand name

A

arcapta neohaler

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37
Q

indacaterol dosage form

A

neohaler (DPI)

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38
Q

indacaterol age group/indication

A

adult; COPD only

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39
Q

olodaterol brand name

A

Striverdi respimat

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40
Q

olodaterol dosage form

A

respimat (soft mist inhaler)

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41
Q

olodaterol age group/ indication

A

adult; COPD only

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42
Q

Salmeterol brand name

A

Serevent Diskus

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43
Q

salmeterol dosage form

A

Diskus (DPI)

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44
Q

salmeterol age groups/ indication

A

4-11, adult, COPD, asthma when used with ICS

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45
Q

LABA adverse effects

A

tachycardia, headache, tremor, hypokalemia (low potassium)

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46
Q

LABA boxed warnings

A

risk of asthma related death when used as a monotherapy; risk of increased hospitalizations in pediatric and adolescent patients

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47
Q

Can children under 4yo used a DPI

A

no; not enough inspiratory flow

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48
Q

LABA counseling points

A

prolonged QT seen with intentional overdoses, not for acute symptoms, helpful for exercise-induced bronchospasm, formoterol and indaceterol capsules should not be taken orally.

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49
Q

What does LABA stand for?

A

Long Acting Beta Agonist

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50
Q

What does LAMA stand for?

A

Long Acting Antimuscarinics

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51
Q

What is the MOA for LAMAs?

A

block the bronchoconstrictor effects of acetylcholine on M3 and M2 receptors

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52
Q

Aclidinium brand name

A

Tudorza Pressair

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53
Q

Aclidinium dosage form

A

Pressair (DPI)

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54
Q

Aclidinium age/ indication

A

adult; COPD only

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55
Q

Glycopyrrolate brand name

A

Seebri Neohaler

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56
Q

Glycopyrrolate dosage form

A

DPI (breezhaler/neohaler); Nebulizer Solution

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57
Q

glycopyrrolate age/ indication

A

adult; COPD only

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58
Q

revefenacin brand name

A

Yupelri

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59
Q

revefenacin dosage form

A

nebulizer solution

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60
Q

revefenacin age group/ indication

A

adult; COPD only

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61
Q

Tiotropium brand name

A

Spiriva

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62
Q

tiotropium dosage form

A

Handihaler (DPI)
Respimat (soft mist inhaler)

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63
Q

tiotropium age groups/ indications

A

Handihaler; adult; copd only
respimat; 12-adult; asthma or COPD

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64
Q

umeclidinium brand name

A

incruse ellipta

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65
Q

umeclidinium dosage form

A

ellipta (DPI)

66
Q

umeclidinium age/indication

67
Q

LAMA adverse effects

A

dry mouth, dizziness, blurred vision, upper respiratory infections, paradoxical bronchospasms

68
Q

fluticasone/salmeterol brand

A

Advair; Airduo & Airduo digihaler

69
Q

fluticasone/salmeterol dosage form

A

Diskus (DPI)
HFA (MDI)
Respiclick (Airduo only) (DPI)

70
Q

fluticasone/salmeterol age groups/indication

A

diskus (DPI)- 4-adult; asthma or COPD
HFA (MDI)- adult only; asthma or COPD

71
Q

Budesonide/ Formoterol brand

72
Q

budesonide/formoterol dosage form

73
Q

budesonide/ formoterol age group/ indication

A

5-11;adult; asthma or COPD

74
Q

budesonide/formoterol class

75
Q

mometasone/ formoterol brand

76
Q

mometasone/formoterol dosage form

77
Q

mometasone/formoterol age group/indication

A

adult; asthma or COPD

78
Q

mometasone/formoterol class

79
Q

fluticasone/vilanterol brand

A

Breo Ellipta

80
Q

fluticasone/vilanterol dosage form

A

ellipta; DPI

81
Q

fluticasone/vilanterol age/indication

A

adult; asthma or COPD

82
Q

fluticasone/vilanterol class

83
Q

olodaterol/tiotropium brand name

A

stiloto respimat

84
Q

olodaterol/tiotropium dosage form

A

respimat (soft mist inhaler)

85
Q

olodaterol/tiotropium age/indication

A

adult; copd only

86
Q

olodaterol/tiptropium class

87
Q

vilanterol/ umeclidinium brand name

A

Anoro Ellipta

88
Q

vilanterol/ umeclidinium dosage form

A

Ellipta/DPI

89
Q

vilanterol/ umeclidinium age/indication

A

adult; COPD only

90
Q

vilanterol/ umeclidinium class

91
Q

Incadaterol/glycopyrronium brand name

A

Utibron Neohaler

92
Q

Incadaterol/glycopyrronium dosage form

A

neohaler (DPI)

93
Q

Incadaterol/glycopyrronium age/indication

A

adult; COPD only

94
Q

Incadaterol/glycopyrronium class

A

LABA/ LAMA

95
Q

Formoterol/Glycopyrronium brand

A

Bevespi Aerosphere

96
Q

Formoterol/Glycopyrronium dosage form

A

aerosphere (soft mist inhaler)

97
Q

Formoterol/Glycopyrronium age/indication

A

Adult; COPD only

98
Q

Formoterol/Glycopyrronium class

99
Q

Formoterol/Aclidinium brand

A

Duaklir Pressair

100
Q

Formoterol/Aclidinium dosage form

A

Pressair (DPI)

101
Q

Formoterol/Aclidinium age/indication

A

adult; copd only

102
Q

Formoterol/Aclidinium class

103
Q

Fluticasone/Umeclidinium/Vilanterol Brand

A

Trelegy Ellipta

104
Q

Fluticasone/Umeclidinium/Vilanterol dosage form

A

Ellipta (DPI)

105
Q

Fluticasone/Umeclidinium/Vilanterol age/indication

A

Adult; Asthma or COPD

106
Q

Fluticasone/Umeclidinium/Vilanterol class

A

ICS/LAMA/LABA

107
Q

Budesonide/ Glycopyrrolate/ Formoterol Fumarate brand

A

Breztri Aerosphere

108
Q

Budesonide/ Glycopyrrolate/ Formoterol Fumarate dosage form

A

Aerosphere (soft mist inhaler)

109
Q

Budesonide/ Glycopyrrolate/ Formoterol Fumarate age/use

A

adult; COPD only

110
Q

Budesonide/ Glycopyrrolate/ Formoterol Fumarate class

A

ICS/LAMA/LABA

111
Q

Leukotriene modifiers MOA

A

block the production of leukotrienes = less inflammation

112
Q

montelukast brand

113
Q

montelukast dosage form

A

tablets; granule packets

114
Q

montelukast age groups/indication

A

1-4,5-11, adults; asthma only

115
Q

montelukast counseling

A

Minor substrate for CYP enzymes (3A4)
not for acute symptom relief
boxed warning for neuropsychiatric events

116
Q

zafirlukast brand

117
Q

zafirlukast dosage form

118
Q

Montelukast class

A

leukotriene modifier

119
Q

zafirlukast age/indication

A

5-11, adult; asthma only

120
Q

zafirlukast counseling

A

1 hour before or 2 hours after meals, Major CYP substrate, minor inhibitor of CYP, at risk for bleeding

121
Q

Zileuton brand

122
Q

zileuton dosage form

A

IR and ER tablets

123
Q

zileuton age/indication

A

adult only; asthma only

124
Q

zafirlukast class

A

leukotriene modifier

125
Q

zileuton counseling

A

Weak CYP inhibitor
take with food

126
Q

zileuton class

A

leukotriene modifier

127
Q

leukotriene modifier adverse effects

A

neuropsychiatric events (agitation, anxiety, suicidal thinking, depression), increased hepatic transaminases
- less effective than ICS/ ICS&LABA

128
Q

theophylline

A
  • theochron
  • tablets, COPD only
  • a methylxanthine
  • similiar side effects as caffeine
129
Q

Omalizumab brand

130
Q

Omalizumab dosage form

A

prefilled syringe for injection

131
Q

omalizumab age/indication

A

6-adult; asthma

132
Q

omalizumab class/ MOA

A

Anti-IgE; inhibits IgE binding on mast cells and basophils; inhibits mediator release and allergic response/inflammation

133
Q

omalizumab counseling

A

adverse: headache, injection site reactions, sinusitis/ upper respiratory tract infections,anaphylaxis

134
Q

Dupilumab brand

135
Q

Dupilumab dosage form

A

syringe for injection

136
Q

Dupilumab; age and indication

A

adult; asthma

137
Q

Dupilumab class/ MOA

A

Anti-IL4/IL13; reduce eosinophil trafficking, IgE reactions, mucus secretion and airway remodeling.

138
Q

What do you need to prescribe Dupilumab?

A

Eosinophil count

139
Q

Roflumilast brand

140
Q

Roflumilast Dosage form

141
Q

Roflumilast age/indication

A

adult; COPD only

142
Q

Roflumilast class/MOA

A

phosphodiesterase-4 inhibitor- inhibits PDE-4 leading to increased cAMP

143
Q

Roflumilast adverse effects:

A

Headache, weight loss, diarrhea, nausea
monitor for liver function and weight.

144
Q

Albuterol HFA Brand Name

A

ProAir HFA, Ventolin HFA, Proventil HFA, ProAir Respiclick, ProAir Digihaler

145
Q

Albuterol dosage forms

A

HFA (most common) and Respiclick (DPI) and Nebulizer solution

146
Q

Albuterol Age and Indication

A

For exacerbations, all ages

147
Q

Albuterol HFA class

A

short acting beta-2 agonist

148
Q

Albuterol Adverse effects

A

high heart rate/ tremor
- arrythmias and tachycardia may be contraindicated

149
Q

Levalbuterol brand

150
Q

Levalbuterol dosage forms

A

MDI and nebulizer solution

151
Q

Levalbuterol age/ indication

A

exacerbations/ all ages

152
Q

Levalbuterol class

A

Short acting B2 agonist

153
Q

Levalbuterol AE

A

tachycardia, tremor, hypokalemia, irritability

154
Q

Ipatropium brand

155
Q

Ipatropium dosage forms

A

MDI and nebulizer solution

156
Q

Ipatropium age/indication

A

all; exacerbations

157
Q

Ipatropium class

A

Short acting anti-cholinergics

158
Q

Ipatropium counseling

A

should not be used alone or as first-line therapy; combine with SABA for asthma exacerbations
AE: dry mouth, urinary retention, infection, sinusitis, bronchitis

159
Q

Ipatropium/ Albuterol brand

A

Combivent respimat

160
Q

Ipatropium/Albuterol dosage form

A

MDI and Nebulizer solution

161
Q

Ipatropium/ Albuterol indication/age

A

all ages; asthma exacerbations

162
Q

systemic corticosteroids used for asthma/COPD exacerbations

A

methylprednisolone, prednisolone, prednisone, dexamethasone, methylprednisolone acetate

Therapeutics (7 decks)

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