Asthma and Allergy Flashcards
upper airway
nasal cavity –> pharynx –> larynx
lower airway
trachea –> primary bronchi –> lungs
classification of airway diseases
- infectious diseases
- obstructive lung diseases
- chronic obstructive pulmonary disease (COPD)
what are the two subtypes of infectious diseases?
- upper respiratory tract infections
2. lower respiratory tract infections
upper respiratory tract infections
- common cold
2. sinusitis
lower respiratory tract infections
- respiratory syncytial virus (RSV)
- tuberculosis (TB)
- pneumonia
- cough
obstructive lung diseases
- lung cancer
2. asthma
COPD
- emphysema
2. bronchitis
asthma
chronic inflammatory disease of the airways with the following clinical features…
what are the clinical features of asthma?
- episodic or chronic symptoms of airway obstruction
- bronchial hyper-responsiveness to triggers
- evidence of at least partial reversibility of airway obstruction
- alternative diagnoses have been excluded
etiology of asthma
specific cause of childhood asthma is unknown but it appears to be multifactorial
environmental exposures that causes asthma
- allergens
- infections
- microbes
- pollutants
- stress
biologic and genetic risks that causes asthma
- immune system
2. lung
which is the most common chronic medical condition of childhood, causing significant morbidity?
asthma
approximately how many children have asthma?
6.3 million children (9%)
T/F: females have more childhood asthma
false, males > females
T/F: females have more adult asthma
true, females > males
T/F: higher SES people have more asthma
false, low SES > high SES
T/F: people in urban areas have more asthma
true, urban > suburban
which race has more people with asthma?
African-American
what percent of asthmatics report onset of asthma prior to age 5?
80%
what is the leading cause of hospitalizations?
asthma
what are the two main types of childhood asthma?
- Type 1
2. Type 2
type 1 childhood asthma
recurrent wheezing in early childhood
what triggers type 1 childhood asthma?
primarily triggered by common viral infections of the respiratory tract
type 2 childhood asthma
chronic asthma associated with allergy that PERSISTS into late childhood and often adulthood
pathogenesis of asthma
- airflow obstruction from bronchoconstriction
- inflammation (mixed with eosinophils), edema, and mucus
- production of pro-allergic, pro-inflammatory cytokines
- mediation of inflammatory process by chemokines
what are the 2 trigger types?
- extrinsic (allergic) asthma
2. intrinsic (non-allergic/idiopathic) asthma
extrinsic (allergic) asthma
triggered activation of mast cells and histamine degranulation following exposure to allergens (dust, pollen, pet, dander, mold, food allergies)
intrinsic (non-allergic/idiopathic) asthma
- tobacco smoke
- air pollution
- strong fumes/odors
- chemicals in air
- respiratory infections
- exercise
- cold air
- anxiety
- stress
- gastroesophageal reflux disease
- aspirin
- NSAID meds
what percent of asthmatics have both tigger types?
10%
type of medications for asthmatics
- rescue medications
2. controller medications
rescue medications
- short-acting beta-agonist
2. anticholinergics
short-acting beta-agonist
albuterol (Proventil)