Asthma

Question 1

MOA Omaluzimab

Answer 1

Inhibits binding of IgE to IgE receptors on the surface of
- Mast cells
- Basophils
- Dendritic cells
Indicated: allergic asthma

Question 2

MOA Mepoluzimab

Answer 2

Anti IL-5
Indicated for: eosinophillic asthma

Question 3

MOA Dupiluzimab

Answer 3

Anti IL-4
Indicated for: asthma + severe eczema

Question 4

Asthma Diagnosis

Answer 4

Bronchodilator response FEV1 or FVC improves >10%

Question 5

Asthma Step-wise Mx

Answer 5

Step 1-2: PRN ICS-Formoterol
Step 3: Low dose maintenance ICS-Formoterol
Step 4: Medium dose maintenance ICS-Formoterol
Step 5: Add-on LAMA e.g. tiotropium. High dose maintenance ICS-Formoterol
Consider MABs / montelukast