Asthma Flashcards
Reversible chronic inflammatory airway disorder, characterized by increased responsiveness of the tracheobronchial tree to various stimuli resting in episodic reversible narrowing of the airway
Asthma
Most common type of asthma
occupational
Which immune responses are responsible for the development of asthma?
Th1 type and Th2 type cytokine response.
Th1 type does what
fights infection
Th2 type immune response does what
contributes to the development of asthma
Inducer stimuli that cause inflammation are
- inhaled allergens
- low molecular weight sensitizers
- viral of mycoplasmal respiratory infections
- noxious gases
Which inducers cause asthmatic bronchoconstriction
- Exercise
- Cold air
- laughter
- emotional upset
- inhaled irritants
What are triggers responsive for sudden severe bronco constriction
- Acetylsalicylic acid
- non steroidal antiinflammatory drugs
- B-adrenergic blockers
- food allergies
- certain food additives
- stings
- bites
- injections
- inhaled allergens
What type of asthma is this: Symptoms <2 days a week night-time <2 times/month SABA use <2/days week effect on normal activity none Lung function test Normal FEV > 80% FEV/FVC normal
Intermittent asthma
Symptoms: > 2 days a week/not daily
nighttime 3-4 times/month
SABA use: >2 days/week not daily and not more than once on any day
Effect on activity: minor limitation
Lung function test: FEV >80% of predicted value
FEV/FVC normal
mild persisten asthma
Symptoms: daily
night time awakening: once a week not nightly
SABA use: daily
Effect on activity: some limitation
Lung function: FEV > 60% but less than 80%
FEV/FVC reduced
moderate
Symptoms: throughout the day night time: often 7 times a week SABA use: several times a day Effect on function: severe limitation lung function: FEV <60% FEV/FVC reduced
severe
What are possible co-morbidities for asthma
- Glaucoma
- HTN
- GERD
- DM
- Arthritis
- Neoplasm
Are serum IgE levels decreased or increased with patients with asthma
Total IgE is elevated in people with asthma which is associated with disease severity
Why does the color of the patients sputum change during an asthma attack
Eosinophil peroxidase