Associations and Triggers

Question 1

Hidradenitis Suppurativa Associations

Answer 1

Smoking

Metabolic syndrome

Obesity

Follicular tetrad: HS, Acne conglobata, dissecting cellulitis of the scalp, pilonidal sinus

PSTPIP1 gene mutations

PAPASH syndrome: Pyogenic arthritis, pyoderma gangrenosum, acne, suppurative hidradenitis

PASH syndrome: Pyoderma gangrenosum, acne, suppurative hidradenitis

Question 2

Psoriasis Triggers

Answer 2

Physical trauma

Streptococcal infection

HIV

Drugs: Antimalarials, Interferon Alpha, TNF-alpha inhibitors, Lithium

Prednisolone withdrawal

Alcohol

Smoking

Stress

Sunlight

Question 3

Psoriasis Associations

Answer 3

Psoriatic arthropathy

Inflammatory bowel disease

HTN

Obesity

Diabetes

Hyperlipidaemia

NAFLD

COPD

Cancer: NMSC, lymphoma e.g. Hodgkin

Psychological distress

Autoimmune diseases: AA, vitiligo, urticaria

Infection risk

Pregnancy risk if severe

Question 4

Erythema Annulare Centrifugum Associations

Answer 4

Most idiopathic

Infections: dermatophytes, candida, poxvirus, parasites

Drugs: diurects, antimalarials, gold

Foods: blue cheese and tomato

Autoimmune endocrinopathies

Neoplasms: lymphoma

Question 5

Lichen Planus Associations

Answer 5

Idiopathic

Drug associated - well established: antimalarials, gold, mercury amalgum, NSAIDs, thiazides

Less well established: Antibiotics, antihypertensives, antimalarials, antidepressants, anticonvulsants, diuretics, metals, NSAIDs, imatinib, IVIg, TNF-alpha

Infections: Syphilis, HSV2, HIV, Amebiasis, UTIs, Hep B/vaccine/HepC/HHV-6/7Myaesthenia gravis, hypothyroidism, thymoma

Hypogammaglobulinaemia

Pemphigus/paraneoplastic pemphigus

Autoimmunity: SLE/DM, Morphoea, Vitiligo, Alopecia areata, Diabetes

Autoimmune chronic active hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis

Question 6

PLEVA Triggers (proposed)

Answer 6

Toxoplasmosis

HSV/EBV/CMV/HHV8

Parvovirus B19

Adenovirus

HIV

Staph/strep

Mycoplasma

Hepatitis B/C

Measles / MMR vaccination

Question 7

Atopic Dermatitis (Rare mimics)

Answer 7

Hyper-IgE syndrome

Hypereosinophilic syndrome

Agammaglobulinaemia

Anhidrotic ectodermal dysplasia

Ataxia telangiectasia

Netherton syndrome

Phenylketonuria

Wiskott-Aldrich syndrome

Question 8

Seborrhoeic Dermatitis Associations and Triggers

Answer 8

HIV/HLTV

Iaotrogenic immunosuppression

Neurological disease (Parkinsons)

Acne, Rosacea, Pityriasis versicolor, Pityrosporum folliculits

Stress

Anorexia nervosa

Alcoholism

Cancer

Age

Question 9

Vitiligo Associations

Answer 9

Thyroid disease (strongest association)

Pernicious anaemia

Addison disease

Diabetes

Hypoparathyroidism

Myaesthenia gravis

Alopecia areata

Morphoea

Lichen sclerosus

Halo naevus

Malignant melanoma

Vogt-Koyanagi-Harada syndrome

Alezzandrini syndrome