Asfarviridae

Question 1

Asfarviridae

Answer 1

• New family
• One genus = Asfivirus
    - African Swine Fever virus (ASFV)
• Lg complex capsule (like pox virus)
• linear dsDNA virus
    - nucleuoproteins surrounded by icosahedral
• cytoplasmic replication
     - macrophages
• envelope 
• environmentally stable
    - heat resistant
    - pH resistant

Question 2

Important Ag protein of African swine fever

Answer 2

p72

Anti-apoptotic gene

Question 3

Transmission of African swine fever

Answer 3

• Ticks
• contaminated animal products -urine, feces, carcass
  - in blood at room temp for 18 months

Incubation pd 5-15 days

Question 4

Pathogenesis of swine fever

Answer 4

initial replication in tonisil/dorsal pharyngeal mucosa
–> reticular cells, monocytes/marophage replication

• high morbidity and mortality
(100% initial outbreak)
- mortality less in endemic areas
(africa, spain, portugal)

Question 5

Clinical signs of African Swine Fever

Answer 5

• marked cyanosis of skin
• pronounced hemorrhage of internal organs
       - LN
       - kidney
       - GI mucosa
       - epicardium
       - endocardium

Question 6

What is the Ddx for african swine fever

Answer 6

1. hog cholera
2. salmonellosis
3. African swine fever