Arthritis Flashcards
What is the commonest joint problem worldwide?
OA
Which type of joints does OA affect
Synovial
Risk factors OA
AGE!! Joint trauma/injury Occupational FH Obesity F>M Gout
Which joint do Heberden’s nodes affect
Distal interphalangeal
Which joint do Bouchard’s nodes affect
Proximal interphalangeal
Clinical signs of OA
Crepitus on movement Pain on movement Heberden's nodes (DIP) Bouchard's Nodes (PIP) Restricted movement Bony enlargement Joint effusion Bony instability
What is the RF in OA
-ve
X-ray signs of OA
Loss of joint space
Osteophytes
Subchondral cysts
Subarticular sclerosis
Ix for OA
Examination
FBC
RF
X-ray
Symptoms OA
Pain Worse on movement and or weight bearing Better on rest Stiffness <30 mins in the morning Swelling around the joint Crepitus Decrease ROM
Difference in morning stiffness between OA and RA
RA prolonged morning stiffness
OA typically lasts <30 mins
Conservative Rx of OA
Patient education
Exercise
Weight loss
Lifestyle change
Non-Pharmacological Rx of OA
Thermotherapy
Electrotherapy
Aids and devices
Manual therapy
Which non-pharmacological Rx do NICE NOT recommend
Acupuncture
Nutraceuticals
Pharmacological Rx of OA
Oral analgesia: NSAIDS
Topical analgesia: Capsaicin
Steroid I/A injections
Surgery options for OA
Joint replacement/Arthroplasty
Osteotomy
Arthrodesis
Who is given surgery in OA
People with severe OA that is impact got QO
When other managements have been tried and failed
Which signs would suggest the diagnosis is NOT OA
Trauma
Prolonged morning stiffness
Rapid deterioration of symptoms
Hot swollen joints
What type of arthritis is gout
Inflammatory
What is the pattern of gout disease
Recurrent attacks
Aetiology Gout
M>F Increasing Age Red meat Alcohol FH gout Obesity Hypertension DM
What causes gout
Elevated levels uric acid in the blood
Triggering factors for gout
Alcohol
Dehydration
Diuretics
Where in the body is gout most common
1st MTP of big toe
Symptoms of gout
Red Hot Swollen Fiery painful joint Peeling overlying skin
Ix for gout
Serum urate (may be helpful) ASPIRATION
What are tophi
Massive accumulations of uric acid
What is the typical presentation of gout
1st MTP of big toe
Hot, red, swollen, painful
Rx acute flares of gout
High dose NSAIDs (Colcichine if NSAIDS CI)
Rest and elevate the joint
Steroid injections
What is given in acute flares of gout if NSAIDS are CI
Colchicine
What is a common side effect of Colchicine
Diarrhoea
When should you treat hyperuricaemia
Single attack of polyarticular gout Urate calculi Renal insufficiency Tophaceous gout If 2nd attack within 1 yr
Which Rx lower uric acid
Xanthine Oxidase inhibitors
Uricosuric agents
How do uricosuric agents work?
They increase rate excretion of uric acid in urine
Should you treat asymptomatic hyperuricaemia
No
Given examples of Xanthine Oxidase Inhibitors
Allopurinol
Febuxosat
Ddx for gout
Septic arthritis
Cellulitis
Reactive arthritis
Pseudogout
What is it important to differentiate gout from
An infection of some sort
e.g septic arthritis
Overproduction causes of hyperuricaemia
Malignancy Lymphoproliferative disorders Tumour lysis syndrome Severe exfoliative psoriasis Drugs Inborn errors of metabolism HGPRT deficiency
Under excretion causes of hyperuricaemia
Elderly Male Renal impairment Hypertension Hypothyroidism Drugs Exercise, starvation, dehydration Lead poisoning
Which joint does Pseudogout typically affect
Knee
What cause pseudo gout
Calcium Pyrophosphate Deposition in the joints