Arthritis Flashcards

1
Q

Categories of arthritis

A

degenerative, inflammatory, crystal deposition, hematologic, metabolic

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2
Q

OA hallmarks

A

asymmetric joints space narrowing, subchondral sclerosis, osteophytosis, subchondral cysts, lack of periarticular osteopenia

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3
Q

? extensive subchondral cystic changes

A

consider CPPD as well as OA

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4
Q

distribution of OA hand

A

DIP, PIP, 1st CMC (commonly 2nd DIP)

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5
Q

Heberden vs Bouchard nodule?

A

soft tissue swelling around H - DIP; B - PIP

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6
Q

Best view for joint space narrowing shoulder?

A

Grashey view, oblique posterior in external rotation

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7
Q

distribution OA foot?

A

MTP, hallux rigidus with dorsal osteophytes; dorsal beaking of talonavicular joint

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8
Q

OA knee?

A

tricompartmental joint space narrowing (mostly medial compartment), osteophytes

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9
Q

OA hip?

A

superolateral migration of hip, less so medial migration

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10
Q

RA hip space narrowing?

A

axial migration –> protrusio deformity

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11
Q

Kummel disease?

A

gas from vertebral body compression fracture (osteonecrosis), different from vacuum phenomenon

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12
Q

DISH diagnosis

A

4 vertebral levels of anterior bridging osteophytes; exuberant osteophytosis; associated with ossification of PLL

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13
Q

OA of SI joint?

A

inferior portion of SI joint (synovial joint); superior part is syndesmotic joint

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14
Q

Erosive OA hands?

A

same as OA (DIP, CMC thumb, PIP); characteristic gull wing appearance of DIP joint (central erosion, marginal osteophytes)

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15
Q

RA overview

A

RF+; antibody directed against IgG which targets synovium and causes symmetric joint pain, swelling, morning stiffness

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16
Q

RA involvement

A

hands/wrist first, feet; advanced cases cervical spine, knees, shoulders, hips

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17
Q

Hallmark of RA

A

marginal erosions, soft tissue swelling, diffuse/symmetric joint space narrowing, periarticular osteopniea, joint subluxations

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18
Q

RA hands?

A

MCP, PIP, carpal articulations; DIP SPARED!

typically radial aspect of 2nd/3rd MCP, ulnar styloid

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19
Q

Boutonnier, Swan neck deformity?

A

Boutonniere: PIP flex, DIP hyperextension

Swan: PIP hyperextension, DIP flex

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20
Q

Late stage RA?

A

anklysosis/fibroosseous joint fusion of wrist

JIA can also cause carpal ankylosis

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21
Q

RA feet?

A

MTP of forefoot and talocalcaneonavicular joint in midfoot

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22
Q

RA hip?

A

protruso deformity; 3 mm male, 6mm female medial deviation of femoral beyond ischial line

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23
Q

RA knee?

A

all three joints + superimposed OA possible

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24
Q

RA spine?

A

cervical spine; no bone production but C1-C2 subluxation, osteopenia, erosions of odontoid, facets, vertebral endplates, spinous processes

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25
Q

RA shoulder

A

high riding shoulder; chronic rotator cuff tears; erosions on lateral aspect of humeral heads

penciling of distal clavicle

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26
Q

Seronegative spondylopathy

A

HLA-B27 +
PAIR
psoriatic, ankylosing spondylitis, inflamatory bowl disease associated arthropathy, reactive arthritis/Reiters arthropathy

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27
Q

Hallmark of spondyloarthropathies

A

sacroilitis of the inferior SI joint

  • Symmetric: IBD, Ankylosing
  • Assymetric: Psoratic, reactive

Unilateral sacroilitis can also be caused by septic arthritis

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28
Q

Types of IBD associated sacroilitis

A

UC, Crohn, Whipple, status post gastric bypass

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29
Q

AS associations

A

young men with HLA B27, pulmonary fibrosis (upper lobe predominant), aortitis, cardiac conduction defects

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30
Q

ankspond early findings, late

A

SI joint: symmetric erosions, widening, sclerosis

Lumbar to cervical

Romanus leisons: erosions of vertebral body endplates (enthesitis) inflammation of ligaments at attachment of annulus fibrosus
Shiny corners: clerosis of romanus lesions
Squaring of vertebral disc margins
Delicate syndesmophytes which then bridge to form bamboo spine

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31
Q

Andersson lesion

A

pseudoarthrosis in completely ankylosed spine

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32
Q

Psoriatic arthritis classic location

A

HANDS HANDS HANDS

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33
Q

Psoriatic arthritis presentation

A

hand involvement, hx of skin psoriasis; normal mineralization; asymmetric SI joint involvement

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34
Q

Hallmark psoriatic arthritis

A

sausage digit soft tissue swelling
pencil in cup erosions at the DIP

telescoping digits or main en lorgnette (opera glass hand) deformity

fluffy periostitis and ill defined erosions

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35
Q

psoriatic arthritis in the foot

A

great toe IP/MTP joints; “ivory phalanx” with otosclerosis

plantar calcaneal spur with periosteal reaction

36
Q

psoriatic arthritis in spine

A

coarse bony bridging sometimes indistinguishable from reactive arthropathy

37
Q

Reactive arthropathy common location

A

FEET FEET FEET

calcaneus; posterior-superior aspect of calcaneus with erosions (bursitis) and achilles tendinitis

38
Q

Hallmarks of reactive arthropathy

A

soft tissue swelling, joint space loss, aggressive marginal erosions, juxta-articular osteopenia

39
Q

reactive arhtropathy in the hands

A

interphalangeal joints and MTP with erosions and diaphyseal periostitis

40
Q

SLE joints

A

subluxations of MCP/PIP, reducible

41
Q

Jaccoud arthropathy

A

secondary to rheumatic fever?

type III ypersensitivity

42
Q

Scleroderma affects first?

A

fingertips –> atrophy of distal soft tissue

acroosteolysis

43
Q

Ddx for acroosteolysis

A

collagen vascular diseases like scleroderma, neuropathy, polyvinyl chloride exposure, thermal injury, hyperparathyroidism, Hajdu-Cheney

44
Q

polymyositis/dermatomyositis hallamrks

A

soft tissue calcifications,

45
Q

calcium hydroxyapatitie deposition disease (HADD)

A

calcific tendinitis of periarticular tissues; NOT IN JOINT!

46
Q

most common location HADD

A

shoulder, supraspinatus tendon

also seen in longus colli

Milwaukee shoulder– intraarticular variant

47
Q

CPDD

A

intraarticular deposition of CPPD crystals which are positively birefringemnt

48
Q

Manifestations of CPPD

A

pseudogout, pseudoosteoarthritis, pseudorehumatoid, pseudoneurpathic

49
Q

Age of CPPD, associations

A

> 50, hemochromatosis/hyperparathyroidism, hypophosphatasi

50
Q

Hallmarks CPPD

A

chondrocalcinosis (calcification of hyaline/meniscal cartilage)

51
Q

Locations for CPPD in the wrist

A

trangular fibrocartilage complex (TFCC) –> SLAC

SLAC is also seen in RA or trauma

52
Q

CPPD in knee

A

patellofemoral compartment isolated is highly suspicious with prominent subchondral cristals

53
Q

CPPD hand

A

2nd and 3rd MCP with hooklike or drooping osteophytes from radial aspect of metacarpal heads

similar to hemochromatosis

54
Q

Gout cause

A

sodium urate deposition in joints

excess uric acid (renal isufficiency)

55
Q

Birifringency of gout

A

negative

56
Q

Common locations/presentation

A

Great toe

overhanging margins, soft tissue gouty tophy; joint space preserved

57
Q

Cause of hemochromatosis arthropathy

A

deposition of iron and CPPD crystals in joints

58
Q

Hemochromatosis presentation

A

bronze pigmentation, diabetes, cirrhosis, CHF, arthropathy; autosomal recess

59
Q

Location for hemochromatosis arthropathy

A

MCP joints with hook like osteophytes at metacarpal heads; involves all MCPs unlike CPPD which is usually 2nd/3rd MCP heads

60
Q

Acromegaly presentation

A

beak like osteophytes of carpal heads; spade like enlargement of tufts

early: widening of joint spaces
later: secondary OA with space narrowing

61
Q

Causes of amyloid arthropathy

A

primary: monoclonal plasma cell dyscrasia; infiltration by beta pleated sheets of amino acids
secondary: chronic inflammation/infection
other: beta 2 microglobulin accomulation on chronic HD

62
Q

What is the shoulder pad sign?

A

bulky soft tissue noduels in shoulder superimposed on atrophic shoulder muscles ; characteristic of amyloidosis

63
Q

Alkaptonuria –> ochronosis

A

intervertebral disc calcifications with disc narrowing

alkaptonuria: defective homogentistic acid oxidase; black urine when oxidized

64
Q

Multicentric reticulohistiocytosis

A

lipid laden macrophages deposited in soft tissue/periarticular tendons –> soft tissue nodules, erosions, sclerotic margins

65
Q

Distribution multicentric reticulohistiocytosis

A

DIP symmetrically; soft tissue nodules; preserved bone; can cause arthritis mutilans

66
Q

Types of hemophilic arthropathy

A

A: factor VIII

B/Christmas dx: factor IX

67
Q

Hallmark hemophilic arthropathy

A

hemarthrosis –> synovial hypertrophy/hyperemia –> epiphyseal enlargement/fusion

nees, elbows, ankles
enlarged radial head/widened trochlear notch
squaring of patella and widened intercondylar notch

68
Q

hemophilic arthropathy can look like?

A

JIA

69
Q

still disease

A

variant of JIA; systemic disorder in kids <5; acute febrile illness, rash, adenopathy, pericarditis, mild arthralgias

70
Q

hallmarks of JIA

A

abnormal bone length (hyperemia), epiphyseal enlargement/ballooning of ends of bones; premature skeletal maturation/physeal fusion; brachydactyly

71
Q

Ddx for cervical spine ankylosis

A

Klippel Feil and JIA

72
Q

Charcot joint

A

neuropathic arthropathy; fragmentation of bone/cartilage; painful swollen joint

73
Q

Causes of charcot joint

A

diabetes (ankle/foot); syringomyelia (upper extreity), alcohol abuse, amyloid, spinal tumors, syphilis/leprosy

74
Q

Forms of neuropathic arthropathy

A

hypertrophic and atrophic

75
Q

Hallmarks of hypertrophic

A

anarchy in joint: destruction, dislocation, debris, disorganizaiton, no demineralization

76
Q

Hallmarks of atrophic form

A

shoulder; resorption of humeral head/surgical like margins

77
Q

bone hallmarks of sarcoid

A

lace like lytic lesions of middle/distal phalanges; polyarthritis

78
Q

ABCDEs of arthritis

A

alignment, bone mineral density/bone creation, calcification/cartilage spaces, distribution, erosions, soft tisssue swelling

79
Q

Reducible vs nonreducible subluxations; dislocations?

A

reducible: SLE, Jaccoud
Nonreducible: rheumatoid –> dislocations

80
Q

Diffuse osteopenia arthropathy?

A

RA

81
Q

periarticular osteopenia

A

RA, early inflammatory arthritis

82
Q

osteophytes arthropathy

A

OA, CPPD, hemochromatosis

83
Q

periosteal bone formation, arthropathy?

A

psoriatic arthritis, reactive arthropathy

84
Q

bone ankylosis in wrist/cervical spine?

A

JIA

85
Q

ankylosis of DIPs

A

psoriatic arthritis

86
Q

ankylosis of wrist?

A

JIA, advanced RA