Arterial Disorders Flashcards
inflammation of vessel wall
vasculitis
presents as fever, malaise, GI issues, myalgia/arthralgia
vasculitis
immune mediated and due to infections
vasculitis
this is due to fibromuscular dysplasia
renal artery stenosis
increased bp due to this; beaded appearance
renal artery stenosis
vasculitis of aorta and branches of extremities, head and neck
large vessel
vasculitis of visceral arteries and branches
medium vessel
vasculitis of arterioles, venules, capillaries
small vessel
giant cell (temporal) arteritis
Takayasu arteritis
large vessel vasculitis
polyarteritis nodosa
Kawasaki disease
medium vessel vasculitis
wegener granulomatosis
Churg-Strauss syndrome
Microscopic polyangiitis
small vessel vasculitis
due to drug hypersensitivity or viral infection
immune complex deposition
drug that forms immune complexes and deposit in large vessel
penicillin
30% of patients w/ polyarteritis nodosa are ____
Hep B +
autoantibodies directed against enzymes of neutrophils
ANCAs
targeted antigen is PR3 of neutrophils; cytoplasmic
c-ANCA
targeted MPO; perinuclear
p-ANCA
c-ANCA
p-ANCA
most common large vessel vasculitis
Giant-Cell (Temporal) Arteritis
granulomatous inflammation; facial pain, HA, painful chewing, diplopia/vision loss
Giant Cell (Temporal) Arteritis
granulomatous vasculitis seen in women <40 yrs
Takayasu Arteritis
reduced bp and weaker pulses in upper extremities; coldness/numbness in fingers
Takayasu arteritis
“pulseless disease”
Takayasu arteritis
segmental thrombosing of medium/small arteries (tibial and radial most common)
thromboangitis obliterans (Buerger Disease)
young men, SMOKERS, claudication (Rx: cessation of smoking)
thromboangitis obliterans (Buerger Disease)
thromboangitis obliterans (Buerger Disease)
systemic vasculitis of medium/small arteries [ RENAL and VISCERAL vessels]
Polyarteritis Nodosa
pulmonary circulation spared in this vasculitis
Polyarteritis Nodosa
episodic intervals
young adults
renal/glomerular involvement
Polyarteritis Nodosa
30% + for Hep B in this vasculitis
Polyarteritis Nodosa
acute febrile, self limited illness
infancy and childhood
Kawasaki Disease
coronary artery involvement leads to ____% of MIs in Kawasaki Disease
20%
presents w/ oral and conjunctival erythema; edema of hands and feet; enlarged lymph nodes (mucocutaneous lymph node syndrome)
Kawasaki Disease
Kawasaki Disease
necrotizing vasculitis
all lesions same age
necrotizing glomerulonephritis and pulmonary capillaries affected
Microscopic Polyangiitis
KIDNEYS and LUNGS affected
Microscopic Polyangiitis
p-ANCA in 70% of patients
Microscopic Polyangiitis
Microscopic Polyangiitis
necrotizing granulomas of upper resp. tract mainly (nasal cavity to alveoli); renal disease
Wegener Granulomatosis
pneumonitis
sinusitis
mucosal ulceration
renal disease
Wegener Granulomatosis
c-ANCA in 95% of patients
Wegener Granulomatosis
Wegener Granulomatosis
necrotizing granulomas w/ eosinophils of LUNGs and HEART
Churg-Strauss Syndrome
asthma
increased eosinophils in blood
numbness/pain in extremities
lungs and heart
Churg-Strauss Syndrome
most common vasculitis in children
Henoch-Schonlein Purpura
presents as rash
IgA immune complexes
after Upper respiratory tract
Henoch-Schonlein Purpura
endarteritis of vasa vasorum of proximal aorta
Syphilitic Aortitis
accounts for 80% of tertiary disease
Syphilitic Aortitis
scarring and can lead to aneurysm
Syphilitic Aortitis
lumen of aorta; seen in what
Syphilitic Aortitis
destruction of blood vessels due to fungi invasion
Aspergillus and Mucor Vasculitis
seen in immunocompromised patients and diabetics
Aspergillus and Mucor Vasculitis
autonomic issue that causes exaggerated response to cold and emotion; pallor or cyanosis to digits (hands/feets)
Raynaud Phenomenon
abnormal connection b/t artery and vein; high output heart failure (due to decrease in bp)
Arteriovenous Fistula
bulging veins
blood clots due to either stasis in veins or turbulent flow in arteries
AV fistula
heart failure and difficulty breathing due to
AV fistula
blood flowing from the high pressure/ high flow artery into the low pressure/low flow vein causes what
causes bulging veins in AV fistula