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Ph Ch 128 2nd Exam > Aromatic Polyketides > Flashcards

Aromatic Polyketides Flashcards

0
Q

Source of 6-methylsalicylic acid

A

Penicillium patulum

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1
Q

5 examples of simple phenols

A

Orsellinic acid, phloroacetophenone, 6-methylsalicylic acid, alternariol, lecanoric acid

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2
Q

Source of alternariol

A

Alternaria tenuis

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3
Q

Oxygenation on alternate carbon atoms

A

Meta oxygenation pattern

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4
Q

Ester from 2 phenolic acids

A

Depside

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5
Q

Examle of depside

A

Alternariol

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6
Q

Consists of 3 rings and a quinone

A

Anthraquinones

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7
Q

Sugars of anthraquinones

A

Glucose and rhamnose (sometimes apiose)

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8
Q

Classification of anthraquinones

A

Oxanthrone, anthrone, dianthrone, anthranol

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9
Q

Relieve constipation

A

Danthron

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10
Q

Treat psoriasis

A

Dithranol

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11
Q

Treat osteoarthritis

A

Diacetylrhein

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12
Q

Relieve depression and photosensitation

A

Hypericin

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13
Q

Source of mycophenolic acid

A

Penicillium brevicompactum

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14
Q

Other name for mycophenolate mofetil

A

N-morpholinoethyl ester

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15
Q

Precursor of mycophenolic acid

A

5-methylorsellinic acid

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16
Q

Inhibitor of mammalian inosine monophosphate dehydrogenase

A

Mycophenolic acid

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17
Q

Source of furochromones (khellin and visnagin)

A

Ammi visnaga

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18
Q

Treat angina pectoris and bronchial asthma

A

Khellin

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19
Q

Synthetic analogue of khellin; for treat,ent and prophylaxis of asthma, hay fever, and allergic rhinitis

A

Cromoglicate

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20
Q

Source of hyperforin and adhyperforin

A

Hypericum perforatum (Fam. Hypericaceae)

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21
Q

Source of humulone

A

Humulus lululus (Fam. Cannabaceae)

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22
Q

Source of usnic acid

A

Usnea and Cladonia sp.

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23
Q

Source of griseofulvin

A

Penicillium griseofulvum

24
Q

Responsible for bitter taste of beer

A

Humulone

25
Q

Antidepressive agent

A

Hyperforin and Adhyperforin

26
Q

Use of usnic acid

A

Antibacterial

27
Q

Use of griseofulvin

A

Antifungal

28
Q

From type III chalcone synthase

A

Chalcones

29
Q

Precursor of chalcones

A

Cinnamoyl Coa

30
Q

From type III stilbene synthase

A

Stilbenes

31
Q

Starter group of stilbenes and chalcones

A

Cinnamoyl CoA

32
Q

Source of resveratrol

A

Vitis vinifera L. (Fam. Vitaceae)

33
Q

Source of lunularic acid

A

Lunularia cruciata (Fam. Lunulariaceae)

34
Q

Precursors of quinoline alkaloids

A

L-tryptophan and secologanin

35
Q

Starter group of quinoline alkaloids

A

Anthraniloyl CoA

36
Q

Use of quinidine

A

For cardiac arrhythmia

37
Q

Use of quinine

A

Antimalarial

38
Q

Starter group of acridine alkaloids

A

Anthraniloyl CoA

39
Q

Source of anacardic acid

A

Anacardium occidentalis L. (Fam. Anacardiaceae)

40
Q

Starter group of anacardic acid

A

Palmitoleoyl CoA

41
Q

Contact allergens

A

Urushiols

42
Q

Sources of urushiols

A

Toxicodendrom radicans and T. toxicaria

43
Q

Source of cannabinoids

A

Cannabis sativa (Fam. Cannabaceae)

44
Q

Starter group of aflatoxin

A

Hexanoate

45
Q

Starter group of tetracyclins

A

Malonamyl CoA

46
Q

Extender of tetracyclins

A

Malonyl CoA

47
Q

Sources of aflatoxin

A

Aspergillus flavus and A. parasiticus

48
Q

Starter group of anthracyclines

A

Propionate

49
Q

Exterder group of anthracyclines

A

Malonyl CoA

50
Q

Source of doxorubicin

A

Streptomyces peuceticus var. caesius

51
Q

Other name for doxorubicin

A

Adriamycin

52
Q

Source of daunorubicin

A

Streptomyces coeruleorubicus

53
Q

Other name for daunorubicin

A

Daunomycin

54
Q

Semi synthetic anthracycline used for treatment of breast cancer

A

Epirubicin

55
Q

Semi synthetic anthracycline that is anti-leukemic

A

Aclarubicin

56
Q

Semi synthetic anthracycline with high activity and low cardiotoxicity

A

Idarubicin

57
Q

Other name for mitozantrone

A

Mitoxantrone

Ph Ch 128 2nd Exam (7 decks)

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