ARDS Flashcards
ARDS definition
Rapid onset of noncardiac pulmonary edema
Progressive refractory hypoxemia
Extensive lung tissue inflammation
Small blood vessel injury
Multisystem organ failure
Pathophysiology of ARDS
Acute lung injury
Unregulated systemic inflammatory response
Damaged capillary membranes leak
Damage alveolar membrane
Fluid enters alveoli
Significant tissue hypoxia results
Metabolic acidosis
Risk Factors for ARDS
Direct Insults
Direct insults
Aspiration of gastric contents
Inhalation injuries
Smoke inhalation
Salt water inhalation
Risk Factors for ARDS
Indirect Insults
Indirect insults
Overall body sepsis
Trauma
Gastrointestinal infections
The greatest risk factor for ARDS is
Aspiration
Initial manifestations of ARDS begin
24–48 hours post insult
Early signs of ARDS
Dyspnea and tachypnea are early signs
S/S of ARDS
Progressive respiratory distress
Hypoxia
Hypercapnia
Agitation, confusion, and lethargy
Diagnostic Tests for ARDS
ABG analysis to determine oxygen levels
Chest x-ray to determine fluid in lungs
Blood tests such as CBC, blood chemistry, and blood cultures
Sputum culture to determine cause of infection
Pharmacological Therapy
No definitive drug therapy
Nitric oxide
- Reduces intrapulmonary shunting
- Improves oxygenation
Surfactant therapy
NSAIDS and corticosteroids are being studied
Nonpharmacologic Therapy
Mechanical ventilation Artificial airways Proper nutrition Adequate amounts of fluids Other clinical therapies
The mainstay of ARDS management is
Mechanical Ventilation
Types of ventilators
Negative vs Positive pressure
Noninvasive
Negative-pressure ventilators
*Create negative pressure externally to draw chest outward and air into lungs
Positive-pressure ventilators
*Push air into lungs
Noninvasive ventilation (NIV)
- Uses face mask
- Sleep apnea
ARDS
What is happening?
A: Atelectasis
R: Refractory hypoxemia (hallmark sign)
D: Decreased lung compliance
S: Decreased surfactant
Complications of Mechanical Ventilation Why? HAP Barotrauma, pneumothorax Cardiovascular effects GI effects
Hospital-acquired pneumonia (HAP): loss of humidity and filtering from upper airway
Barotrauma: PEEP
Pneumothorax: PEEP
Cardiovascular effects: Increased pressure in the chest decreases cardiac output
Gastrointestinal effects: Misplacement of tube (monitor for abdominal distention)