ARDS Flashcards

1
Q

Define ARDS

A

No single disease entity, but a syndrome

Multiple symptoms and signs that are pathologically related

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2
Q

What is the consequences of ARDS on oxygenation

A

Refractory Hypoxemia

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3
Q

How is ARDS defined by Berlin

A

Time of onset

CXR

Respiratory failure not explained by heart failure

Impaired oxygenation

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4
Q

How is heart failure found

A

Pulmonary capillary wedge pressure less to or equal to 18mmHg

Pulmonic closed and mitral open. Pascals principle says pressure will match LV

Echocardiogram

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5
Q

What is the onset time of ARDS

A

7 days

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6
Q

What is seen on a CXR of ARDS

A

Bilateral infiltrates

(Can’t be explained by pleural effusion, lobar or lung collapse, or pulmonary nodules)

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7
Q

Normal P/F

A

400-500

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8
Q

Mild ARDS P/F

A

201-300

With PEEP or CPAP

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9
Q

Moderate ARDS P/F

A

101-200

W/ PEEP

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10
Q

Severe ARDS P/F

A

Less or equal to 100

W/ PEEP

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11
Q

What happens if Pi decreases

A

Negative pressure pulmonary edema

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12
Q

What happens when you have frequent deep gasp for air

A

Self-induced lung injury (SILI)

Negative pressure pulmonary edema
(Pleural effusion)

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13
Q

What causes a decrease in Pi

A

High altitude

Repeated gasp for air

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14
Q

What causes high altitude pulmonary edema (HAPE)

A

Exercising at high altitudes before acclimation

Reduced PB decrease interstitial pressure relative to blood pressure

(Deep breaths for air)

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15
Q

What happens if intracapillary oncotic pressure decreases

A

Low albumin cause release of fluid causing ascites, lower extremity edema, pleural effusion, pulmonary edema

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16
Q

What causes low oncotic pressure in the capillaries

A

Malnutrition
Liver disease
Kidneys disease

17
Q

Other than what can be explained by sterlings law, what else can cause non-Cardiogenic edema

A

Lymphatic insufficiency

18
Q

Is negative pressure and high altitude pulmonary edema transudate or exudative

A

Transudate

Increases venous return to RV causing demand to move forward (hydrostatic)

19
Q

Why is low oncotic pressure due to malnutrition, liver disease, and kidney disease transudate.

A

Low albumin causes fluid to leak and causes pulmonary edema with low protein

20
Q

Medical dictionaries definition of sepsis

A

The presence in the blood or other tissues of pathogenic microorganisms or their toxins

21
Q

Surviving sepsis campaign definition of sepsis

A

A life-threatening organ dysfunction caused by dysregulated host response to infection

22
Q

What does surviving sepsis campaign do

A

Authoritative guidelines for the identification, assessment, and treatment of of sepsis

23
Q

Key differences between non and Cardiogenic edema

A

Non is caused by injury causing increased permeability

Protein rich plasma enters interstitium and leaks into alveoli

24
Q

The three stages of ARDS

A

Edema
Hyaline membrane
Interstitial fibrosis

25
Q

Three phases of ARDS

A

Exudative
Proliferation
Fibrotic

26
Q

When is the exudative phase of ARDS

A

Within 72 hours

27
Q

When is the proliferation phase of ARDS

A

4-14 hours

28
Q

When is the fibrotic phase of ARDS

A

Within 14-21 days

29
Q

Is ARDS homogeneous

A

No. Stress strains can occur with impacted alveoli harming health alveoli

30
Q

What happens to type 2 cells with ARDS

A

Proliferate and swell

31
Q

What happens to the alveoli walls with ARDS

A

They become fibrotic with hyaline

32
Q

What occurs during the exudative phase ARDS

A

Interstitial edema
Acute and chronic inflammation
Type 2 cell hyperplasia
Hyaline membrane formation

33
Q

What occurs during the proliferation phase of ARDS

A

Resolution of pulmonary edema
Proliferation of type 2 cells
Squamous metaplasia

34
Q

What occurs during the fibrotic phase of ARDS

A

Some patients
Obliteration of normal cell
Fibrosis
Cyst formation
Varying levels of damage

35
Q

What does the American Thoracic Society recommend for ARDS management

A

Neuromuscular blockade
VV-ECMO
Systemic Corticosteroids
High PEEP
Prone
Lung Protective Ventilation

36
Q

What intervention for ARDS is strongly recommended against according to (ATS)

A

Prolonged recruitment maneuver
High frequency oscillatory ventilation

37
Q

Describe high-frequency oscillatory ventilation

A

Delivers sub-Vt at a rate of 60cycles/min