ARBs

Question 1

contraindications for all (2)

Answer 1

The combination of an angiotensin-II receptor antagonist with aliskiren is contra-indicated in patients with an eGFR less than 60 mL/minute/1.73 m2

The combination of an angiotensin-II receptor antagonist with aliskiren is contra-indicated in patients with diabetes mellitus

Question 2

SE postural hypotension is more common in pt …

Answer 2

with intravascular volume depletion, e.g. those taking high-dose diuretics

Question 3

common SE include

Answer 3

Abdominal pain; asthenia; back pain; cough; diarrhoea; dizziness; headache; hyperkalaemia; hypotension; nausea; postural hypotension; RI

Question 4

true or false - increased risk of infection with candesartan

Answer 4

true

Question 5

monitoring

Answer 5

Monitor plasma-potassium concentration, particularly in the elderly and in patients with renal impairment.

Question 6

interaction with aliskerin

Answer 6

Candesartan increases the risk of renal impairment when given with Aliskiren. Manufacturer advises use with caution or avoid Aliskiren in selected patients.

Question 7

which electrolyte disturbance can it cause

Answer 7

hyperkalaemia

Question 8

ARBs and lithium

Answer 8

Candesartan potentially increases the concentration of Lithium. Manufacturer advises monitor concentration and adjust dose.

Question 9

first dose hypotension?

Answer 9

yes

Question 10

which ones licensed in HF

Answer 10

candes
losart
valsar