Aquifer 3 Flashcards
Define orthostasis.
Reduction of systolic or diastolic blood pressure of at least 20 or 10 mmHg respectively, measured 3 minutes after going from supine to standing or sitting.
When should AFib be suspected?
Dizziness, syncope, dyspnea, or palpitations
How is AFib diagnosed?
EKG
The prevalence of AFib increases with what factors?
Age, severity of CHF or valvular heart disease
Define new onset AFib.
AFib less than 72 hours total duration
What are the two types of chronic AFib?
Persistent
Paroxysmal - recurs and then reverts back to normal rhythm spontaneously, variable periods of normal sinus rhythm between episodes
List the 4 major cardio/cerebrovascular mechanisms of TIAs or stroke.
- Embolic (most commonly from the heart or carotid artery; arrhythmias may produce emboli)
- Thrombotic (native within the intracranial vasculature)
- Cardiogenic (decreased cerebral perfusion due to decreased CO, severe hypotension, or hypoxemia)
- Hemorrhagic (secondary to pathologic changes in the brain due to aging, smoking, HTN, hyperlipidemia)
85% of strokes are caused by ___.
Vascular occlusion (thrombotic)
What are two other categories of possible mechanisms of TIA/stroke?
Hematologic (hyperviscosity or myeloproliferative syndromes, vascular obstruction from sickle cell, severe anemia, and conditions associated with hypercoagulable states)
Vascular (HTN leading o thrombosis or bleeding, atherosclerotic emboli from carotid or vertebral plaques, extrinsic compression of cranial vessels, vasospasm, vasculitis)
Individuals experiencing TIA symptoms have been shown to have a ___% chance of having a stroke within 1 week and a ___% chance of having a stroke within 1 month.
8-12; 11-15
If given within ___ hours, IV tPA has proven benefit in salvaging hypoxic brain tissue. Intra-arterial therapy improves functional outcomes if it can be given with ___ hours.
3; 6
Thrombolytic therapy should not be delayed while awaiting lab results unless what 3 things?
- Clinical suspicion of a bleeding abnormality or thrombocytopenia
- Patient has received heparin or warfarin
- Use of anticoagulants is not known
Causes of AF with Rapid Ventricular Response?
Fever, myocarditis, pericarditis, volume contraction, thyrotoxicosis, endogenous catecholamines, and AV nodal dysfunction
What is the difference between rate and rhythm control of AF with RVR?
Rate control - controlling the HR with IV diltiazem, beta-blockers, or verapamil to improve blood flow; does not delay immediate need for emergency stroke treatment
Rhythm control - cardioversion (electric shock or medications); both methods carry a risk of stroke, greatest in patients who have had AFib for more than 48 hours who have not been given 3 weeks of prior anticoagulant therapy
Symptoms of right parietal infarct?
Right-hand dominant patients will have left hemiplegia; right MCA infarcts affecting the right pareital hemisphere may also have difficulties with spatial and perceptual abilities; may also have denial of stroke disability
Symptoms of a stroke in the brain stem?
Respiratory impairment, affects vital functions of BP, HR, consciousness
Symptoms of a left MCA stroke?
Expressive and receptive aphasia and right facial weakeness
Compare the facial effects of a central facial nerve injury (stroke) vs. a peripheral facial nerve injury (Bell’s palsy).
Central (stroke) - spares forehead due to bilateral central control
Peripheral - weakness in the forehead
What are 3 common stroke complications?
- Aspiration pneumonia
- Malnutrition/dehydration
- Pressure sores
What is the difference between basic and instrumental activities of daily living?
Basic - bathing, dressing/undressing, eating, transferring from bed to chair and back, voluntarily control urinary and fecal discharge, using the toilet, walking
Instrumental - not necessary for fundamental functioning, but enable the individual to live independently within a community - light housework, preparing meals, taking medications, shopping for groceries/clothes, using the phone, managing money
Which ethnic group has the highest rates of CHD in America?
African Americans
1/3 of stroke survivors experience ___.
Post-stroke depression (mood disorder due to the direct physiological effects of another medical condition)
What does the TUG Test measure?
Mobility and fall risk in people who are able to walk on their own
Describe the TUG Test.
Sit in the chair with your back to the chair and your arms resting in your lap. Without using your arms, stand up from the chair and walk 10 feet . Turn around, walk back to the chair, and sit down again. Time from starting to rise from the chair to sitting down. Give 1 practice trial and 3 actual trials. Average the results.
Explain the results of the TUG test.
<10 seconds - freely mobile
<20 seconds - mostly independent
20-29 seconds - variable mobility
>30 seconds - impaired mobility
What is one of the most sensitive tests for upper extremity weakness?
Pronator drift
What are the 3 options recommended by the AHA/ASA for First Stroke Prevention?
- Adjusted-dose warfarin (target INR 2-3) - all patients with nonvalvular AF deemed to be at high risk and many deemed at moderate risk who can receive it safely
- Antiplatelet therapy with aspirin - low-risk and some moderate-risk patients with AF (patient preference, bleeding risk, access to monitoring)
- Dual anti-platelet therapy with clopidogrel and aspirin - offers more protection against stroke than aspirin alone, but with an increased risk of major bleeding
What are the 2 options recommended by the AHA/ASA for Stroke Prevention in patients wiht a history of stroke or TIA?
- Patients with ischemic stroke or TIA with paroxysmal or permanent AF: anticoagulation with vitamin K antagonist (target INR, 2.5, range 2-3)
- Patients unable to take oral anticoagulants - aspirin alone
What antithrombotic agents are indicated for the prevention of first and recurrent stroke in patients with nonvalvular AF?
Warfarin, dabigatran, apixaban, rivaroxaban
What validated instrument applies known CV risk factors to provide calculated guidance to weight the risks and benefits of anticoagulation?
CHADS2 score
The PROTECT program recommends 8 secondary prevention goals after a stroke - what are the 4 aimed at treatable risk factors?
- Hyperlipidemia - high-intensity statin
- HTN - antihypertensive treatment (goal - 130/80)
3 and 4?
The PROTECT program recommends 8 secondary prevention goals after a stroke - what are the 4 aimed at modifiable lifestyle risk factors?
- Smoking - stop
- Diet - Mediterranean diet to reduce risk + limit sodium to 2,400 mg/day or less if HTN
- Physical activity - moderate-to-vigorous intensity activity 3-4x/week for 40 minutes/session
- Stroke education - warning signs, awareness of individual risk factors
What are the high intensity statins and doses?
Atorvastatin (40 or 80 mg) or Rosuvastatin (20 mg)
When should a CT/MRI be done when evaluating a patient with suspected acute ischemic stroke?
Before initiating any specific therapy to treat acute ischemic stroke
List the recommended tests for the initial emergency evaluation of a patient with suspected acute ischemic stroke.
- CT/MRI
- Renal function/electrolytes
- EKG
- Markers for cardiac ischemia
- CBC and PT/PTT
- O2 Sat (hypoxic patients should receive O2)
DDx - Dizziness/Lightheadedness with FOcal Neurologic Findings
Most likely - seizure, stroke, TIA, CAD, medication side effect
Less likely - brain tumor, hypoglycemia, temporal arteritis, hypokalemia, periodic paralysis, hemiplegic migraine
What are some possible presenting features of seizure?
Aura of dizziness or lightheadedness, other auras arising from the temporal lobe; may occur with sudden and extreme elevations of BP associated with papilledema
Seizures may be followed by a brief period of temporary ___ on one side of the body; may also affect speech and vision. What is the average duration?
Paralysis (Todd’s paralysis); 15 hours, but can last from 30 minutes to 36 hours
What is a hallmark of seizure disorder?
Amnesia for the event and aleration of consciousness
When should a seizure be considered unlikely?
If the patient has recall of the event, no post-ictal period of confusion, and no evidence of focal findings, oral injury, or urinary/fecal soiling
What is a cardinal feature of stroke?
Focal neurologic deficits such as arm paresthesia
True or false - dizziness and lightheadedness are not common presentations of brain tumor.
True
Patients with temporal arteritis may present with ___ and ___.
Amaurosis fugax (transient monocular loss of vision) and cranial bruits
NSAIDs may increase the effectiveness of ___ and decrease the effectiveness of ___.
Sulfonylureas; HTN medications
GPTAL?
Gravida (# pregnancies) Term Preterm Abortions (spontaneous or induced) Living
DDx - pediatric fever, sore throat, cough, and rash
Most likely - viral pharyngitis, GABHS pharyngitis
Less likely - epiglottitis, pertussis, mononucleosis, retropharyngeal abscess, viral croup, allergic rhinitis/pharyngitis