Aqueous And Vitreous Humor Flashcards

1
Q

What is the aqueous humor

A

Clear, alkaline liquid that occupies the anterior and posterior chambers of the eye

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2
Q

How does aqueous compare to blood plasma

A

It has less proteins and glucose

More lactic acid and ascorbic acid

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3
Q

What is the function of aqueous

A

-provide necessary metabolites (oxygen, glucose) to the avascular lens and cornea

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4
Q

Where is the aqueous made

A

Pars plicata

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5
Q

Where is the aqueous secreted to

A

Posterior chamber

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6
Q

What is the function of ascorbic acid

A
  • potent reducing and antioxidant agent
  • fighting bacterial infections
  • detoxifying reactions
  • formation of collagen in fibrous tissue
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7
Q

What is the aqueous humor made from

A

Blood

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8
Q

What cells secrete the aqueous humor

A

The non-pigmented epithelium of the ciliary processes

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9
Q

What the volume of aqueous humor

A

0.2 microliter

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10
Q

How often is aqueous replaced

A

Every 100 minutes

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11
Q

What are the 5 main components of the aqueous humor

A
Bicarbonate
Lactic acid
Ascorbic acid
 Chlorides
Glucose
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12
Q

T/F there is variation between the aqueous in healthy and diseased eyes

A

NO

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13
Q

What is the vitreous humor

A

Dilute solution of salts, soluble proteins, and HA

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14
Q

What is the vitreous contained in

A

Mesh work of collagen

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15
Q

What is water composition of the vitreous

A

98.5-99.7%

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16
Q

What is the magnesium composition of the vitreous

17
Q

What is thought to play a significant role in the production and secretion of several connective tissue macromolecules of the vitreous body

A

Non-pigmented epithelium of the ciliary body

18
Q

Where is the collagen content of the vitreous the highest

A

At the base

Next at posterior cortex
Lowest at center

19
Q

What is the diameter of the collagen fibrils that fill the vitreous body

20
Q

T/F the density of the collagen fibril network differs throughout the vitreous

21
Q

What are the types of collagen present in the vitreous

22
Q

What is the order of collagen types present from greatest amount to lease

23
Q

What is fibrillin

A

Used to form microfibrils

Minor component of vitreous

24
Q

What is fibrillin a MAJOR component of

25
A mutation in fibrillin-1 causes ectopic lens in this condition
Mafrans
26
What is opticin
Glycoproteins Leucine rich Binds growth hormones and GAGs
27
What are GAGs
Long chains that attach t protein core and undergo various degrees of modifications
28
What is the 2nd MAJOR component of the vitreous
HA
29
What is HA
A hydrophilic macromolecule that is located in specific sites of collagen fibril network
30
Where is the concentration of HA the highest
Posterior cortex and it gradually decreases centrally and anteriorly
31
What is the function of HA
Stabilize the network formed collagen trends
32
How does HA differ from other GAGS
- Is not synthesized covalently - not linked to core protein - not sulfated
33
What are Hyalocytes
Vitreous class that make HA, glycoproteins for collagen fibrils, phagocytic properties
34
Do Hyalocytes have a constant appearance
No it varies based on its activity at a given time
35
Where are fibroblasts located in he vitreous
Near the base of the ciliary body and near optic disc
36
Fibroblasts make up what percent of the vitreous cell population
Less than 10%
37
What is the function of fibroblasts
Synthesize collagen fibrils that run anteroposteriorly and are active in pathological conditions
38
What are the vitreous humors functions
- Physical support - storage of metabolites for the retina and lens and avenue for movement of these substances - shock absorber - transmits and refracts light, aiding in rays focusing on the retina
39
What when the HA surrounding the collagen fibrils begin to degenerate
They coalesce and the space where the HA was is filled in th a more liquid substance FLOATERS