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Ocular Block 7 > Aqueous And Vitreous Humor > Flashcards

Aqueous And Vitreous Humor Flashcards

1
Q

What is the aqueous humor

A

Clear, alkaline liquid that occupies the anterior and posterior chambers of the eye

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2
Q

How does aqueous compare to blood plasma

A

It has less proteins and glucose

More lactic acid and ascorbic acid

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3
Q

What is the function of aqueous

A

-provide necessary metabolites (oxygen, glucose) to the avascular lens and cornea

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4
Q

Where is the aqueous made

A

Pars plicata

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5
Q

Where is the aqueous secreted to

A

Posterior chamber

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6
Q

What is the function of ascorbic acid

A
  • potent reducing and antioxidant agent
  • fighting bacterial infections
  • detoxifying reactions
  • formation of collagen in fibrous tissue
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7
Q

What is the aqueous humor made from

A

Blood

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8
Q

What cells secrete the aqueous humor

A

The non-pigmented epithelium of the ciliary processes

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9
Q

What the volume of aqueous humor

A

0.2 microliter

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10
Q

How often is aqueous replaced

A

Every 100 minutes

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11
Q

What are the 5 main components of the aqueous humor

A 
Bicarbonate
Lactic acid
Ascorbic acid
 Chlorides
Glucose
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12
Q

T/F there is variation between the aqueous in healthy and diseased eyes

A

NO

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13
Q

What is the vitreous humor

A

Dilute solution of salts, soluble proteins, and HA

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14
Q

What is the vitreous contained in

A

Mesh work of collagen

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15
Q

What is water composition of the vitreous

A

98.5-99.7%

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16
Q

What is the magnesium composition of the vitreous

A

???

17
Q

What is thought to play a significant role in the production and secretion of several connective tissue macromolecules of the vitreous body

A

Non-pigmented epithelium of the ciliary body

18
Q

Where is the collagen content of the vitreous the highest

A

At the base

Next at posterior cortex
Lowest at center

19
Q

What is the diameter of the collagen fibrils that fill the vitreous body

A

8-16 mm

20
Q

T/F the density of the collagen fibril network differs throughout the vitreous

A

TRUE

21
Q

What are the types of collagen present in the vitreous

A

2, 9, 11

22
Q

What is the order of collagen types present from greatest amount to lease

A

2>9>11

23
Q

What is fibrillin

A

Used to form microfibrils

Minor component of vitreous

24
Q

What is fibrillin a MAJOR component of

A

Zonules

25
Q

A mutation in fibrillin-1 causes ectopic lens in this condition

A

Mafrans

26
Q

What is opticin

A

Glycoproteins
Leucine rich
Binds growth hormones and GAGs

27
Q

What are GAGs

A

Long chains that attach t protein core and undergo various degrees of modifications

28
Q

What is the 2nd MAJOR component of the vitreous

A

HA

29
Q

What is HA

A

A hydrophilic macromolecule that is located in specific sites of collagen fibril network

30
Q

Where is the concentration of HA the highest

A

Posterior cortex and it gradually decreases centrally and anteriorly

31
Q

What is the function of HA

A

Stabilize the network formed collagen trends

32
Q

How does HA differ from other GAGS

A
  • Is not synthesized covalently
  • not linked to core protein
  • not sulfated
33
Q

What are Hyalocytes

A

Vitreous class that make HA, glycoproteins for collagen fibrils, phagocytic properties

34
Q

Do Hyalocytes have a constant appearance

A

No it varies based on its activity at a given time

35
Q

Where are fibroblasts located in he vitreous

A

Near the base of the ciliary body and near optic disc

36
Q

Fibroblasts make up what percent of the vitreous cell population

A

Less than 10%

37
Q

What is the function of fibroblasts

A

Synthesize collagen fibrils that run anteroposteriorly and are active in pathological conditions

38
Q

What are the vitreous humors functions

A
  • Physical support
  • storage of metabolites for the retina and lens and avenue for movement of these substances
  • shock absorber
  • transmits and refracts light, aiding in rays focusing on the retina
39
Q

What when the HA surrounding the collagen fibrils begin to degenerate

A

They coalesce and the space where the HA was is filled in th a more liquid substance
FLOATERS

Ocular Block 7 (9 decks)

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