Approaches to increase drug sensitivity

Question 1

L-asparaginase

Answer 1

To stop acute lymphoblastic leukemia tumor growth by converting asparagine to aspartic acid to inhibit protein synthesis.

Question 2

Imatinib

Answer 2

Specific tyrosine kinase (essentially, Bcr-abl) inhibitor which leads to inhibition of tumor cell proliferation in Chronic myelogenous leukemia.

Question 3

Trastuzumab

Answer 3

A monoclonal antibody which inhibits activation of a human epidermal growth factor receptor, HER2. But not for all the breast cancer patients.

Question 4

Bevacizumab

Answer 4

Monoclonal antibody that inhibit angiogenesis that supports the tumor growth.

Question 5

All-trans-Retinoic acid

Answer 5

Promotes terminal differentiation of leukemic promyelocytes(cancer cells to normal cells.)

Question 6

Interferon alpha

Answer 6

Binds to the IFN-receptors and triggers signaling cascades to decrease the cell proliferation and enhancing immune activities.

Question 7

Sipuleucel-T

Answer 7

Cancer treatment vaccine to program a patient’s own immune system to seek out cancer spreading in the body.