Anticancer drugs Flashcards
What types of cancer are prevalence in Men / Women.
Prostate, Lung (leading death), and Colorectal / Breast, Colorectal, and Lung (leading death). Occurrence of Melanoma increasing in both gender.
What is the first and second leading cause of cancer death for both gender
Lung(1st) and Colorectal(2nd)
Problem of detecting Cancer
Most of symptoms are too general and it might be too late by the time you find the cancer .
Gompertzian growth
Developing model of solid tumors in which rate of cancer growth hits plateaus after slow initial growth and rapid proliferation and growth.
What would happen if you fail to kill all the cancer cells with drugs
Reoccurrence of tumor.
Main targets of anticancer drugs
Block DNA synthesis to damage, cause improper coiling of DNA, stop proliferation, and sometimes transcription and translation; thus, protein functions.
Principles of classical cancer chemotherapy which account for 10% of cured treatment
Eliminate all the malignant cells, Don’t rely on host mechanisms to eliminate moderate number of cancer cells, and cell-kill follows first order kinetics.
Benefit of surgical removal of cancer before chemotherapy.
Can remove persistent secondary tumors, shortens the duration of therapy, an prolong ones survival, but not cure.
Types of chemotherapeutic drugs
Alkylating agents (to bind DNA covalently), Anti-metabolites (disturbs availability of building blocks for DNA synthesis), Anti-tumor antibiotics does not kill bacteria, but affect protein function, Hormonal agents (used in breast and prostate cancer).
Function of cell cycle phase specific drugs
Effective for rapidly and slowly proliferating cells to induce plateau; whereas, other drugs are more effective for rapidly proliferating cells.
Cancer cells can develop _____ which promotes to ______.
multi-drug resistance
Drug efflux
