Approach to the Cardiovascular Patient Flashcards

1
Q

What are signs and symptoms of an MI?

A
  • Prolonged >30 min of chest pain
  • Pain radiation to both arms
  • Tachycardia
  • Diaphoresis
  • N/V
  • Dyspnea
  • Feeling of impending doom
  • S4 gallop
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2
Q

How does one diagnose an MI?

A

Pt. with chest pain and >1mm ST elevation in 2 contiguous leads OR a new left bundle branch is having an acute MI and should receive immediate therapy

Do not wait for troponin results, the ECG is diagnostic here

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3
Q

What labs/imaging are helpful in diagnosing an MI?

A

Measurement of blood levels of proteins that leak out of irreversibly damaged myocytes (myocardial injury is not always due to infarction, may be due to heart failure, myocarditis, pericarditis)

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4
Q

What are the cardiac enzymes that can be used to diagnose an MI? What is the most sensitive and specific cardiac enzyme for diagnosing an MI?

A

Cardiac specific troponins: Proteins that regulate calcium-mediated contraction of cardiac and skeletal muscle .

Most sensitive and specific, these are not normally detectable in the circulation) LR+ 47 / LT- 0.3.
o cTnT
o cTnI

Troponins may not be elevated until 4-6 hours after an acute event:
• Once elevated, troponin levels can remain high for days-weeks
• ECG changes occur at the onset of myocardial compromise, while elevations in troponin may take longer

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5
Q

(T or F) Myocardial injury is not always due to infarction.

A

True. Can be due to heart failure, myocarditis, pericarditis.

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6
Q

What is dyspnea?

A

Dyspnea: Uncomfortable awareness of breathing that is inappropriate to given level of exertion

Dyspnea on exertion (DOE): In and of itself without chest discomfort is an anginal equivalent in the patient with coronary artery disease

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7
Q

What are the organ systems in the differential diagnosis of dyspnea?

A
Cardiovascular
•	Coronary artery disease
•	Heart failure
•	Valvular heart disease
•	Dysrhythmia 
•	Cardiac tamponade
•	Constrictive pericarditis 
•	Cardiomyopathy
Pulmonary
•	Obstructive pulmonary disease
•	Restrictive pulmonary disease
•	Pulmonary hypertension
•	Pulmonary embolism
•	Pneumonia
•	Pneumothorax 

Hematologic
• Anemia

Physical deconditioning

Mental/emotional
• Anxiety

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8
Q

Define orthopnea

A

Orthopnea: Dyspnea that occurs when the patient is supine and improves when patient sits up.
Increase venous return (preload) on lying down.
Relieved by elevating the head and upper torso (pillows when sleeping).

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9
Q

Define Paroxysmal Nocturnal Dyspnea

A

Paroxysmal Nocturnal Dyspnea: Episodes of sudden dyspnea that awaken the patient from sleep brought on by lying flat after the patient has been asleep for a few hours. Pt sits up and goes to a window for air (may be accompanied by coughing, wheezing (cardiac asthma). Fluid accumulation in lungs due to reabsorption of dependent edema with fluid in the interstitial and or alveolar spaces of the lungs.

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10
Q

What may be labs or imaging that is indicated for evaluating a patient with dyspnea?

A

Labs: CBC, comprehensive metabolic panel, B-type natriuretic peptide (BNP)* *Becomes elevated in heart failure

Imaging: Chest X-ray, echocardiogram, stress testing, spirometry, full pulmonary function tests

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11
Q

What are palpatations?

A

Palpitations: Awareness of the heartbeat. Typically, normal sinus rhythm is not perceived, and palpitations usually reflect changes in cardiac rate, rhythm, or contractility.

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12
Q

What are important history questions in evaluating a patient with palpitations?

A
  • Quality: Skipping, Racing, Fluttering, Pounding, Stopping, Flip-flop
  • Regularity: Regular/Irregular
  • Timing: Sudden, Rapid, Slow
  • Duration
  • Frequency
  • Triggers: Coffee, Tea, Alcohol
  • Associated symptoms: Lightheadedness/syncope, dyspnea, chest pain
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13
Q

What is the differential diagnosis of palpitations?

A
Palpitations are not always cardiac in origin:
•	Hyperthyroidism
•	Anemia
•	Electrolyte abnormalities
•	Anxiety
•	Caffeine
•	Sympathomimetic drugs:
•	Albuterol
•	Amphetamines
•	Cocaine
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14
Q

What labs and imaging would one consider when evaluating a patient with palpitations?

A

Labs: CBC, Comprehensive metabolic panel, TSH

Imaging: ECG, Holter monitor (24-48 hours), Ambulatory telemetry monitoring: Up to 30 days, Patch testing: Zio patch (14 days), Implantable event recorders: (Up to three years), Echocardiogram

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15
Q

What is syncope versus lightheadedness?

A

Lightheadedness: In presyncope, lightheadedness and a sense of impending faint without loss of consciousness.

Syncope: Transient loss of consciousness. Sudden, brief loss of consciousness with loss of postural tone followed by spontaneous revival

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16
Q

What are the organ systems involved in your differential diagnosis of syncope?

A
  • Cardiovascular
  • Nervous
  • Metabolic
17
Q

What are must-not-miss diagnoses of syncope?

A
  • Cardiac syncope: 20%
  • Seizure
  • TIA/stroke
  • Trauma
  • Intoxication
  • Hypovolemia
18
Q

What are causes of syncope?

A
  • Neurally mediated: 45%
  • Vasovagal syncope
  • Situational
  • Secondary to carotid sinus hypersensitivity
  • Orthostatic hypotension: 10%
  • Medications: 5-15%
  • Antihypertensive
  • Vasodilator
  • Hypoglycemic
19
Q

1What are cardiac causes of syncope?

A

• Dysrhythmia (more often)
• Structural cardiac abnormality (less often):
o Left ventricular outflow tract (LVOT) obstruction

20
Q

What are neurologic causes of syncope?

A

Postural orthostatic tachycardia syndrome (POTS)

21
Q

What are metabolic causes of syncope?

A

Hypoglycemia

22
Q

Syncope: What are red flags noted as part of the history that may suggest a cardiovascular etiology?

A
  • Syncope on exertion
  • Murmur on auscultation
  • Palpitations prior to syncope
  • Family history of sudden cardiac death
23
Q

What are appropriate labs and imaging to order when evaluating syncope?

A

Labs: CBC, Comprehensive metabolic panel, Capillary blood glucose

Imaging: ECG, Holter monitor (24-48 hours), Ambulatory telemetry monitoring: (Up to 30 days), Patch testing: Zio patch: (14 days), Implantable loop recorders (Up to three years)
Echocardiogram: as indicated
• Abnormal ECG
• Risk factors for heart disease
• Murmur indicative of valvular heart disease
• Exercise-induced syncope

24
Q

What is neutrally mediated syncope?

A

Neutrally mediated syncope: Increased vagal activity causes decreased heart rate and blood pressure

25
Q

What is Vasovagal syncope caused by? Sxs?

A
  • Strong emotions:
  • Pain
  • Fear
  • Sight of blood
Prodrome:
•	Nausea
•	Sweating
•	Abdominal discomfort
•	Yawning
•	Warmth
•	Pallor
•	Diminished hearing
•	Blurred vision
26
Q

What is situational syncope caused by?

A
  • Cough
  • Straining: Urination, BM
  • Valsalva maneuver
27
Q

What is Carotid sinus hypersensitivity syncope caused by?

A
  • Pressure on carotid sinus:
  • Head rotation
  • Shaving
  • Tight collar
28
Q

What is orthostatic hypotension?

A

Decrease in: Systolic blood pressure: >20 mmHg / Diastolic blood pressure: >10 mmHg

29
Q

Pathophysiology of orthostatic hypotension

A
  • Normally, the gravitational stress of sudden standing causes blood to pool in the veins of the legs and trunk:
  • The subsequent decrease in venous return reduces CO and BP
  • In response, baroreceptors in aortic arch and carotid bodies activate autonomic reflexes to rapidly return BP to normal
  • Sympathetic nervous system increases HR and contractility and increase vasomotor tone
  • Simultaneous parasympathetic inhibition also increases HR
30
Q

What are causes of orthostatic hypotension?

A

Excessive fall in blood pressure when an upright position is assumed:
Medications – vasodilators
Volume depletion – blood loss, GI bleed, dehydration
Autonomic dysfunction – failure of normal mechanisms (sinus tachycardia, vasoconstriction) to compensate for temporary decrease in venous return that occurs with standing

31
Q

Compare and contrast pitting and non-pitting edema.

A

Edema: Accumulation of excess fluids in the extravascular interstitial space
Pitting Edema: Low protein concentration, increased capillary pressure, heart failure
Non-pitting edema: High protein concentration , lymphedema

32
Q

What is the pathophysiology of edema?

A

Increased movement of fluid from intravascular to interstitial space or decreased movement of water from the interstitium into the capillaries or lymphatic vessels

Increased renal sodium retention may also be a primary cause of fluid overload resulting in edema

Intravascular to interstitium:
• Capillary hydrostatic pressure (pushes fluid out of vessels)
• Interstitial oncotic pressure (pulls fluid into interstitium)
• Capillary permeability (allows fluid to escape into interstitium)

Interstitium to intravascular:
• Intravascular plasma oncotic pressure (pulls fluid intravascular)
• Interstitial hydrostatic pressure (pushes fluid out of interstitium)

33
Q

What are the organ systems to consider in the differential diagnosis of edema?

A

Cardiovascular:
• Heart failure
• Constrictive pericarditis
• Venous obstruction: Deep venous thrombosis/Pelvic mass
• Venous insufficiency
• Lymphatic obstruction: Pelvic mass/Lymphedema
• Lymphatic destruction: Radiation
Liver: Liver failure
Kidney: Advanced kidney disease of any cause, Nephrotic syndrome
Pulmonary: Pulmonary hypertension/Obstructive sleep apnea
Infection: Cellulitis
Trauma: Burn
Nutritional: Hypoalbuminemia
Musculoskeletal: Baker cyst

34
Q

What is the differential diagnosis of leg cramping/pain?

A

Cardiovascular: Peripheral arterial disease, Deep venous thrombosis
Skin: Cellulitis
Musculoskeletal
Nervous: Peripheral neuropathy, Spinal stenosis