Approach To Renal Complaint Flashcards

1
Q

What is proteinuria?*

A

Protein in the urine

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2
Q

What is glucosuria?

A

Glucose in the urine

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3
Q

What is hematuria?

A

Blood in the urine

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4
Q

What is albuminuria?

A

Albumin in the urine

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5
Q

What is dysuria?

A

Painful urination

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6
Q

What is polyuria?

A

Frequent urination

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7
Q

What is GFR?

A

Glomerular filtration rate

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8
Q

What is CrCl?

A

Creatinine clearance

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9
Q

What is AKI?

A

Acute kidney injury
Impairment of renal filtration and excretory function over days to weeks that results in retention of nitrogenous and other waste products, normally cleared by the kidney
Clinical diagnosis not a structural injury to kidney

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10
Q

What is CKD?

A

Chronic kidney disease

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11
Q

What is ESRD?

A

End stage renal disease

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12
Q

What is uremia?

A

Elevated levels of BUN

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13
Q

What is blood urea nitrogen (BUN)?

A

Urea nitrogen is a waste product created when the liver breaks down proteins
Urea nitrogen travels from the liver to kidneys and is excreted as waste product
BUN is a blood test that allows clinicians to gauge kidney function

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14
Q

What is creatinine?

A

Waste product of muscle breakdown
Created constantly and properly functioning kidneys excrete this waste product
Cr is a blood test that allows clinicians to gauge kidney function

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15
Q

What is tested in a basic metabolic panel?

A

Na, K, Cl, HCO3, BUN, Cr, glucose

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16
Q

What is tested in a comprehensive metabolic panel?

A

BMP + liver function tests (AST, ALT, Alkphos, total bilirubin, T protein, albumin)

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17
Q

What’s included in a urinalysis?

A

Specific gravity (tests urine concentration), pH, protein, glucose, blood, bilirubin, nitrites, leukocytes

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18
Q

What is urine microscopy?

A

Looking at urine under the microscope for urine casts/sediment to aid in clinical diagnosis

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19
Q

AKI may progress to chronic kidney disease if the renal dysfunction is not resolved in how long?*

A

3 months

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20
Q

What are the major risk factors for AKI?

A

Old age, CKD, HTN, DM, exposure to nephrotoxins (NSAIDs, Abx), fluid overload, trauma, malignancy and sepsis

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21
Q

What are the 3 categories of AKI?

A
Pre-renal AKI (insult/injury occurring before kidney - ex. hypotension) 
Intrinsic AKI (injury occurring at the level of kidney - ex. Glomerulonephritis) 
Post-renal AKI (injury occurring down stream to/after the kidney - ex. Bladder outlet obstruction)
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22
Q

Describe a clinical scenario for pre-renal AKI

A

History of fluid loss or poor fluid intake? (Vomiting, diarrhea, hemorrhage)
History of decreased effective circulatory volume? (Heart failure)
History of new or chronic use of medications? (NSAIDs, BP meds)
PE finding of volume depletion (dry mucous membranes, tachycardia, hypotension and poor skin turgor)

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23
Q

Describe a clinical scenario for intrinsic AKI

A
History of CKD, DM, HTN?
History of recent URI?
New meds? (Abx, NSAIDs, BP meds) 
Systemic sx present that would make you think of auto immune disease? (Oral ulcers, CP, SOB, cough, hemoptysis, abd pain) 
Hematuria? 
Foamy urine? (Proteinuria)
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24
Q

Describe a clinical scenario for post renal AKI

A

Hx of kidney stones (flank pain with hematuria)
Hx of prostate issues (think of elderly male with urinary hesitancy, frequency, and sense of incomplete vomiting)
Hx of pelvic neoplasm (think of pt being up to date on cervical cancer and prostate cancer screening)
Hx of Foley catheter (acute or chronic in nature)

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25
Complaint specific questions to ask?
Urinary frequency, hesitancy, foamy urine, urine color, urine smell, flank pain, pain with urination, hx of kidney stones
26
Describe evaluating volume status during exam
Jugular venous pressure (distended or flat veins?), oral mucosa (dry, tongue fissuring), capillary refill, skin testing, ascites, lower extremity pitting edema, sacral edema (elderly or immobile pts)
27
Which labs should always be obtained on all pts with AKI?
BMP* -increase in Cr 1.5x the pt’s baseline or >0.3mg/dL increase -BUN:Cr >20:1 suggestive of pre-renal AKI urinalysis with urine microscopy* Other tests that may be useful include urine albumin/creatine ratio, renal ultrasound, renal biopsy
28
What are some treatments for AKI?
Depends on etiology (pre-renal, intrinsic or post renal pt) Correct underlying disease if possible Mostly supportive (avoid HTN, discontinue nephrotoxins, renal replacement if needed usually with hemodialysis) Time is nephrons
29
Pre-renal pts need what?
IV fluid
30
Intrinsic renal pt need what?
Underlying cause of disease addressed
31
Post renal pts need what?
Remove obstruction
32
What is the definition of chronic kidney disease?
Either present for 3 months 1. GFR <60 ml/min/1.73m^2 2. Markers of kidney damage including protein in urine*, abnormal urinary sediment*, abnormal biopsy, abnormal imaging, electrolyte abnormalities, hx of kidney transplantation
33
If it is <3 months with GFR <60 ml/min and/or markers of kidney damage present then the pt has what?
Acute kidney injury
34
What are the risk factors for CKD?
DM, HTN, cardiovascular disease, AKI* | Metabolic syndrome or obesity, smoking, high cholesterol, HIV, hep C, cancer or cancer Tx
35
Signs and sx for CDK are the same as what?
AKI
36
What questions should also be asked during the history for CKD?
Questions about new sx of uremia Nausea/vomiting, confusion, pruritus, metallic taste in mouth, fatigue, anorexia Pericardial friction rub (pericarditis and pericardial effusion) Asterixis (movement of the wrist; hand will flop) Uremic frost
37
Which 3 tests are used to ID most CKD patients?
GFR (estimated GFR), proteinuria (urine albumin to creatinine ratio or urine protein to creatinine ratio) and urinalysis with microscopy
38
What are the limitations for testing GFR to ID CKD pts?
Not reliable when GFR >60m/min Not reliable in AKI (rapidly chaining creatinine) Not reliable in low muscle mass (cachexia, paraplegia, etc)
39
What complications can occur with CKD?
CVD, chronic kidney disease-mineral and bone disease (CKD-MBD), anemia of CKD, electrolyte abnormalities, metabolic acidosis, volume overload, uremia, HTN
40
How is CKD treated?
``` Correct/treat underlying disease if possible (HTN, DM, etc) Mostly supportive (prevent HTN, avoid volume overload, avoid nephrotoxins (NSAIDs), treat anemia, renal replacement if needed ```
41
What is renal replacement therapy (RRT)?
Hemodialysis, peritoneal dialysis, renal transplantation (living v deceased donor)
42
What are the indications for dialysis?*
A - severe acidosis E - electrolyte disturbance (usually hyperkalemia) I - ingestion (ex. Ethylene glycols, methanol, etc) O - volume overload U - uremia
43
What is asymptomatic bacteriuria?
Presence of bacteria w/out sx
44
What is cystitis?
Symptomatic bladder infection
45
What is prostatitis?
Symptomatic prostate inflammation due to infection
46
What is pyelonephritis?
Symptomatic infection of the kidneys
47
What is the pathogenesis of a UTI?
Occurs when there is colonization of urethra meatus or urine with a uropathogen Most commonly E. coli (70-90% of the time)
48
What are the most common causes of a UTI?
Fecal contamination, outflow obstruction, sexual activity, catheterization
49
What are the sx of cystitis?
Dysuria, urinary frequency, urinary urgency, suprapubic pain, hematuria
50
What are the sx of pyelonephritis?
Dysuria, urinary frequency, urinary urgency, suprapubic pain, hematuria, fevers, flank pain, costovertebral angle tenderness, nausea/vomiting
51
What are the basic labs for cystitis?
CBC, BMP, urinalysis | Urine culture* (look for >100,000 cfu/mL on urine culture)*
52
What is the diagnostic approach for pyelonephritis?
``` History and PE are important Basic labs (CBC, BMP, urinalysis, urine culture, microscopy, +/- blood cultures) Imaging (in severe cases CT scan of the abd and pelvis is the gold standard) ```
53
What is Lloyd’s sing (punch)?
Special test for kidney inflammation/distention Pain to deep percussion in the are of the CVA Positive test = pain in the area of the CVA with deep percussion -implies pyelonephritis, nephrolithiasis
54
What is the tx for a UTI?
Abx if the following criteria are met (symptomatic, >100,000cfu) Duration of Abs will vary based off UTI type and severity (cystitis 3-5 days; pyelonephritis 7-14 days)
55
What is nephrolithiasis?
Kidney stones | Caused by precipitation in minerals in the kidney and ureters that were soluble in the blood
56
What are the types of kidney stones?
Calcium oxalate (80%) >>>> calcium phosphate** Auric acid Struvite Cystine
57
What are the sx of nephrolithiasis?
Unilateral sharp colicky pain Location of stone indicates locations of pain Stone located at kidney or renal pelvis = flank pain Stone located at lower ureter = groin/lower abd pain Urinary sx (polyuria, dysuria, hematuria, urinary urgency are common)
58
What is the diagnostic approach for nephrolithiasis?
HPI and PE are important Basic labs + stone composition analysis Imaging (non contrast CT preferred; ultrasound preferred for pts where radiation contraindication like pregnant women or children)
59
How is nephrolithiasis treated?
Supportive care (treat pain and nausea, consider IV fluids) If recurrent or strong family hx find cause to treat If concerned for contaminant infection treat with Abx Severe cases (large stones) may require surgical intervention
60
What are the reflex levels for sympathetic to the genitoruinary tract including bladder?
T10-L2
61
What are the sympathetic levels for the upper ureter?
T10-11
62
What are the levels to the lower ureter?
T12-L2
63
What are the parasympathetics to the upper ureter?
Vagus N (OA, AA)
64
What are the parasympathetics to the bladder and lower ureter?
S2-4 (sacrum)
65
Describe the anterior Chapman reflex points
Kidneys: about 1 in lateral and 1 inch superior to umbilicus (10 and 2 position) Ureters: none Bladder: umbilicus Urethra: superior surface of pubic bone relative positions
66
Describe posterior Chapman points*
Kidneys: lateral to spinous process of L1 Ureters: TP of L2 Bladder: TP of L2
67
What are Chapman reflex points?
Group of palpable points occurring in predictable locations on the anterior and posterior surfaces of the body that are reflections of the visceral dysfunction or disease Viscerosomatic reflex of both diagnostic and tx value Can be manipulated to reduce adverse sympathetic influence of a particular organ or visceral system