approach to liver diseases

Question 1

Itching preceding liver disease

Answer 1

PBC

PSC

Question 2

Jaundice in gilbert syndrome is aggravated by

Answer 2

fasting

stress

Question 3

scales for grading activity in liver disease

Answer 3

histology activity index

ISHAK histology scale

Question 4

protease inhibitors inhibiting UGT1A1

Answer 4

atazanavir

indinavir

Question 5

toxicity of which anti cancer drug is increased in gilbert syndrome

Answer 5

irinotecan

Question 6

hepatic histology in gilbert

Answer 6

lipofuschin pigmentation

Question 7

Drugs causing ‘adaptation’

Answer 7

isoniazid
statins
valproate
phenytoin

Question 8

Types of drug induced cholestasis

Answer 8

bland- estrogen
inflammatory-phenothiazines,amoxycillin-clavulunate,oxacillin,erythromycin
sclerosing cholangitis-floxuridine
ductopenic cholestasis-carbamazepine,chlorpromazine,TCA

Question 9

drugs which cause more hepatotoxicity in CLD patients

Answer 9

aspirin
methotrexate
isoniazid
antiretroviral therapy

Question 10

drug causing primary billiary cirrhosis like lesion

Answer 10

chlorpromazine

Question 11

drug causing pseudo alcoholic liver injury

Answer 11

amiodarone

Question 12

DILI commonly associated with hypersensitivity reactions

Answer 12

phenytoin

TMP-SMX