Applying to Modifying Addiction: Using Varenicline.

Question 1

Addictions are linked to pleasure as a result of dopamine release. How could we help diminish cravings?

Answer 1

• Reducing dopamine release.

Question 2

What is Varenicline?

Answer 2

• Trade name: Champix.

- Drug prescribed to help quit smoking.

Question 3

How does Varenicline work?

Answer 3

• Affects dopamine release in brain.
• Binds to nicotine receptors and tricks brain into thinking its had nicotine, which leads to a small release of dopamine.
• This small dopamine release alleviates cravings and withdrawal symptoms.
• Reduces the rewarding effects of nicotine by blocking nicotine ability to access receptors and activate dopamine release.
• Smoke cigarette = less pleasure = may help quit.

Question 4

Does it work?

Answer 4

• It has proven to be effective (extra support for role of dopamine).
• Most effective alongside other methods (dopamine alone can’t explain addiction).