appetite regulation Flashcards
carbon dioxide production/oxygen usage
respiratory quotient (tissues)
carbon dioxide output/oxygen uptake
respiratory exchange ratio (lungs)
90% protein nitrogen eliminated via
urine
what control hunger/appetite and satiety
hypothalamus
lateral nuclei serve as
feeding center (lesion cause inanition)
ventromedial nuclei serve as
satiety center and inhibits the feeding center (lesions cause hyperphagia)
fats and carbs cause ___ release and inhibit eating
CCK and insulin
intestinal release of _____ inhibit feeding
peptide YY (PYY) and glucagon like peptide (GLP)
___ stimulates eating
ghrelin
released from oxyntic cells of stomach
ghrelin
decreased body temperature ___ hunger
increases
increased energy sotres inhibit food intake. leptin, released from fat cells, ___ appetite
reduces
most obese people are not leptin deficient but instead ____
leptin resistant
anorexogenic
decrease feeding
orexogenic
increase feeding
neuropeptide Y (NPY) agouti related peptide (AGRP) enodrphins, endocannabinoids cortisol ghrelin
increased feeding (orexogenic)
alpha-melanocyte stimulating hormone insulin and GLP leptin CCK norepinephrine
decreased feeing (anorexogenic)
restriction food intake causes an increase in ___ and decrease in ____
increase: hunger hormone ghrelin
decrease: satiety hormones leptin, PYY, CCK, insulin
decreases in absorption of fat soluble vitamins, soft stools and anal leakage
orlistat
increases serotonin in brain and is associated with pulmonary hypertension and valvulopathy
fenfluramine
blocks voltage dependent Na channels, augments of activity at some subtypes of GABA A receptors
topiramate
opioid recepter antagonist (antidepressant)
naltrexone
inhibits synaptic dopamine, NO
bupropion
opposite of obesity (extreme weight loss)
inanition
decreased appetite (CNS mechanisms)
anorexia
severe metabolic disorder of increased energy use and wasting
- cancer, aids, cytokines IL 6
cachexia
scaliness of skin, failure of growth in young animals, failure of reproduction, keratinization of the cornea
vit a def.
causes lesions of the CNS and PNS (polyneuritis)
thiamine def (B1) - beriberi
weakness and poor smooth muscle/gland function; severe cases cause the disease pellagra
niacin def.
replicating cell types; red blood cells (pernicious anemia)
B12 def.
anemia
folic acid def.
scurvy, breakdown of connective tissue and poor wound healing
vit c def.
rickets
vit d def.
deficiency induced pathology
vit e def.