Appendix C: Blood Brain Barrier Flashcards

1
Q

How do nutrients get to the brain

A

Through the circulatory system

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2
Q

What are tight junctions

A

Gaps that prevents the free flow of substances into and out of the blood

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3
Q

How are the tight junctions different in the brain than elsewhere

A

The ednothelial cells are overlapping

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4
Q

What do the feet of the astrocytes do

A

Contribute to blood brain barrier which regulates what comes in and goes out

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5
Q

What are lipid soluble substances

A

Some gasses and steroids

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6
Q

What kind of gasses are lipid soluble

A

O2 and CO2

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7
Q

What steroids are lipid soluble

A

Sex hormones and cortisol

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8
Q

What is albumin

A

A protein carrier

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9
Q

What does albumin do

A

Steroids stick to these so it can travel through the cell membrane

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10
Q

What are the transport systems for amino acids

A

L-system and A-system

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11
Q

What are the transport systems of ions

A

Channels, sodium potassium pump

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12
Q

Where is there more K+ and more Na+

A

More K+ inside the cell and more Na+ outside the cell

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13
Q

Is there any blood brain barrier in the circumventricular organs

A

No

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14
Q

Why is there no blood brain barrier in the circumventricullar organs

A

Need to detect molecules in the blood and need to excrete into blood

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15
Q

What does the subfornical organ do

A

Circulating angiotensin II acts here to increase water intake

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16
Q

What does the organum vasculosum of the lamina terminalis do

A

Osmoreceptor controlling vasopressin secretion and thirst

17
Q

What does the posterior pituitary do

A

Secretes hormones into blood

18
Q

What does the area postrema do

A

A chemoreceptor trigger zone that initiates vomitting in response to chemical changes in the plasma

19
Q

What does the pineal body do

A

Secretes melatonin hormone into blood