apk exam 3 Flashcards
nervous system
the master controlling/communicating syst of the body
- rapid, specific signals cause IMMEDIATE responses by the body
- employs electrical & chem. means to send messages from 1 cell to another
- faster than endocrine
endocrine system
communicates by chemical messengers, hormones, secreted into the blood
- takes longer for hormones in bloodstream to get to target organ
3 overlapping functions of the nervous system
- sensory function: monitors changes inside and outside body; sensory info moves along a neuron, towards the brain
- integration function: CNS receives and interprets sensory input & makes a decision for axn
- motor function: motor neurons elicits response by activating effector organs
tip: SIM
central nervous system (CNS)
brain + spinal cord
peripheral nervous system (PNS)
- all nervous tissue outside of CNS
- cranial & spinal nerves that can have sensory/motor functions
- connects CNS to rest of the body (muscles, glands, sensory receptors)
- 2 branches: afferent and efferent division
afferent (sensory) division of PNS
- made of somatic and visceral sensory nerve fibers
- conducts impulses from receptors to the CNS
efferent (motor) division of pNS
- made of motor nerve fibers
- conducts impulses from the CNS to effectors (muscles & glands)
- 2 types: somatic nervous system & autonomic
somatic nervous system
- part of PNS efferent division
- somatic motor - voluntary control
- conducts impulses de CNS to skeletal muscles
autonomic nervous system
- pt of PNS efferent division; a system of motor neurons that innervate the smooth muscle, cardiac muscle, and glands of the body
- autonomic inactivation or inhibition of the viscera; visceral motor (involuntary!!)
- conducts impulses de CNS to cardiac, smooth muscles, and glands
- sympathetic and parasympathetic divisions
sympathetic nervous system (thoracolumnar division of ANS)
mobilizes body syst during activity - fight or flight
- responds to stresses (physical and emotional)
- increase body functions that support physical activity
- decrease digestive & urinary function
- PNS, efferent, autonomic
parasympathetic nervous syst
- PNS, efferent, autonomic
- rest & digest
- conserves E, restore body E, promotes house-keeping functions during rest
- decr body functions that support physical activity
- incr digestive and urinary function
nervous tissue
- made of 2 types of cells: composed of excitable neurons and non-excitable cells, neuroglia
special characteristics of neurons
- conductivity: able to send elect. signals from 1 body pt to another called action potential/nerve impulses
- extreme longevity: neurons can live and funct. for lifetime
- can’t divide: cannot replace themselves if destroyed (few exceptions)
- high metabolic rate: require constant supply of o2 and nutrients
tip: Conie meticulously long divides (conductivity, metabolism, longevity, divide)
neuron structure
- cell body: aka soma/neurosoma; where nucleus and organelles are
- dendrites: extensions from cell body; act as receptive regions; signals then move down to cell body
- axon hillock: signal moves from cell body to here; tapered area
- axon: where signal travels away from cell body; acons can be really short or really long
- schwann cells: neuroglia; insulate axon; forms myelin sheath - sheath is not continuous
- node of Ranvier: gaps between myelin sheath
- terminal arborization/axon terminal: have terminal boutons; secretory region
structural classification of neurons
- multipolar
- bipolar
- unipolar
multipolar neuron
many processes extend de the cell body; all are dendrites except for a single axon
- most common
bipolar neuron
2 processes extend de the cell bod; 1 is a fused dendrite and the other is an axon
- ex: commonly are sensory neurons in eyes, nose, nasal cavity
unipolar neuron
1 process extends de the cell bod and forms central & peripheral processes. which together comprise an axon
functional classfication of neurons
grouped according to the direction in which nerve impulse travels relative to the CNS
- afferent: towards CNS = SENSORY
- efferent: away from CNS = motor
- interneurons = within CNS = association
synapse
sites of communication b/w 1 cell to another
- 3 types:
- axosomatic
- axodendritic
- axoaxonic
tip: SAD
presynaptic neuron
neuron tht is sending the signal to another cell
postsynaptic neuron
neuron tht is receiving signal from another cell
axosomatic
axon synapses with the cell body
axodendritic
synapse b/w axon terminal and the dendrites of the postsynaptic neuron
axoaxonic
synapse b/w axon terminal of the presynaptic neuron and the axon terminal of the postsynaptic neuron
components of synapse
- axon terminal
- synaptic vesicles; whatever they contain will be released via exocytosis; ex: neurotransmitters
- nerve impulses - travel down from cell body to axon terminal -> signal exocytosis of neurotransmitters into SYNAPTIC CLEFT -> neurotransmitters bind to receptors on receiving side/postsynaptic cell
neuroglia
- similar to neurons; have processes
- different from neurons: non-excitable, don’t respond to electrical signals; smaller, more numerous (10:1), can divide thru/o life
- cover all non-synaptic surfaces of neurons
- 4 types of CNS neuroglia
- 2 types of PNS neuroglia
CNS neuroglia
- astrocytes
- microglial
- ependymal cells
- oligodendrocytes
tip: observe epic astroids through microscopes
astrocytes
- most abundant cns neuroglia
- incr neurotransmitter reuptake
- signal increased blood flow to active brain regions; they attach to blood vessels
- controls the ionic environment around neurons
- star-shaped
microglial cells
cns neuroglia; least abundant glial cells
- smallest gial cells
- macrophages of the CNS - eat up microorgs/pathogens
ependymal cells
cns neuroglia
- simple, ciliated epithelium
- forms a permeable lining of the ventricles, aka brain cavities filled w/ cerebrospinal
ogliodentrocytes
- cns neuroglia
- have processes tht form myelin sheaths around long axons in the cns
- electrically insular cns axons
- nodes of ranvier present
- looks like octopus - coils and forms insulatory sheaths - sheaths not continuous
pns neuroglia
- satellite cells: cover around cell body of neuron
- schwann cells: form myelin sheath
- different from oligodendrocytes bc they don’t have processes - the ENTIRE cell, itself, coils/wraps around axon
- they surround ALL axons in PNS, but only some axons have myelin sheath; ex: if we have 20 axons, schwann cells can just lightly wrap/bundle these together -> this is not considered a myelin sheath bc the coiling is not layered
- nodes of ranvier present along axon
myelin sheaths
concentric layers of plasma membrane of Schwann cells or oligodendrocytes tightly wrapped
- insulate axon; makes electrical conductivity faster
myelinated axon of PNS process
- schwann cell wraps around axon
- it wraps around the axon; wrapping plasma membrane loosely around in successive layers
- cell cytoplasm is forced from b/w the mmrbanes. the light membrane wrapping surrounding the axon forms the myelin sheath
- organelles and nucleus get pushed to the outside regions
diseases of myelin sheath
- degenerative disorders
- multiple sclerosis
- tay-sachs
multiple sclerosis
- neuroglia degenerate
- myelin replaced by hard scar tissue
- nerve conduction disrupted - double vision, tremors, numbness, speech defects
- can get various symptoms depending which myelin is affected - PNS or CNS
tay-sachs disease
hereditary; in Jewish infants
- abnormal accumulation of glycolipids in myelin sheath
*disrupts conduction of nerve signals
*blindness, loss of coordination, and dementia
*fatal b4 age 4
nonmyelinated axons in PNS
- schwann cell surrounds multiple axons, but doesn’t have concentric layers/tight coils so no insulation
conduction speed of nerve fibers
- speed @ which nerve signal travels along a nerve fiber depends on 2 factors:
1. diameter of fiber (larger = faster)
2. myelinated = faster - signal conduction occurs along the surface of a fiber
*lrgr fibers have more surface area and conduct signals more rapidly
*myelin further spreads signal conduction
grey and white matter of the cns
grey matter: butter-fly shaped; consist of short nonmyelinated interneurons, neuroglia, and cell bodies of interneurons and motor neurons
* ex: cerebral cortex, central cavity
white matter: groupings of myelinated axons; fiber tracts of myelinated and nonmyelinated axons; consist of neuroglia
*DO NOT RELATE TO PNS AT ALL
pns nerves
- cable-like ORGANS with parallel arranged axons
- around an entire nerve, we have a fibrous connective tissue sheath, called EPINEURIUM
- within the nerve, we have bundles of axons called FASICLCES
- PERINEURIUM encase fasiclces
- within fasicles, we have individual axons that are covered by its own ENDONEURIUM
(very similar to what occurs with muscle tissue)
integration of the pns and cns
- they can work together: info from peripheral goes to central and then central tells what peripheral can do
- ex: reflexes
REFLEX = rapid, automatic, motor response to stimuli
reflex arc involved
reflex
rapid, automatic, motor response to stimuli
- 4 important properties of a reflex:
- require stimulation: reflexes are not spontaneous axns, but r responses to sensory input
- quick: involve few, if any, interneurons and minimum synaptic delay
3.: involuntary: occur w/o intent and difficult to suppress; automatic response
4.: stereotyped: occur essentially the same way every time
tip: stick stereo in quick
stick = put something in = input/stimulation
STEREOtyped
INvoluntary
quick
reflex arc
- receptor
- sensory neuron
- integration center
- motor neuron
- effector
ex: getting pricked by needle
receptor senses pain, sensory neuron brings signal to spinal cord; spinal cord = integration b/w pns and cns; interneurons synapse with motor neuron to send signal to effector; effector carries out axn, like contracting muscles to remove finger
knee-jerk (patellar) reflex
- ex of a stretch/tendon reflex
- dr taps on ur patellar tendon -> hammer pulls tendon a bit
- sensory/strecth receptor: quadriceps senses slight pull
- sensory afferent nueron: sends signal to spinal cord; DIRECTLY SYNPASES WITH MOTOR EFFERENT - does not to go all the way to the brain
- motor efferent neuron: sends signal to quadriceps/effector
- effector: quadricepts contract and extends the knee
- how many neurons and synapses are involved?
- 2 neurons - 1 afferent, 1 efferent
- 1 synapse
thus, this is called a monosynaptic stretch reflex
- reciprocal inhibition also occurs
reciprocal inhibition
reflex phenomenon that prevents muscles from working against e/o by inhibiting the antagonist
- ex: during knee reflex, ur hamstring are inhibited while quadriceps contract
types of reflexes
- stretch
- withdrawal
flexor/withdrawal reflex
- contraction of flexor muscles resulting in the withdrawal of a limb from an injurious stimulus
- ipsilateral reflex arc: communication b/w sensory and motor neurons occur on same side of spinal cord
- ex: u touch a thumb tack and u quickly pull away
- sensory receptor detects prick
- sensory afferent neuron sends signal to spinal cord
- interneuron: sensory afferent neuron synapses with interneuron, which synapses with motor efferent neuron
- motor efferent neuron: sends signal to effector
- effector: carry out action; biceps contract
- ex of polysynaptic reflex; 3 neurons, 2 synapses
do all reflexes have to cause a response to the same side of the body as where the stimulus occurred?
no
crossed extension reflex/contralateral reflexes possible
- ex: u go to the beach and step in something sharp- 1 foot lifts off/withdraws, but the other needs to contract & extend to keep u balanced or else u fall
directional terms for the CNS
- rostral: towards the snout
- caudal: towards tail; in humans, caudal does not mean our back, but the end of our spinal cord, near the tail bone
major divisions of the brain
- cerebrum
- diencephalon
- cerebellum
- brain stem
cerebrum
largest part of the brain, over 80% of brain’s mass -> left and right hemisphere
- cerebral hemispheres; cortex, white matter, basal nuclei
- wrinkles incr SA
- associated with lateral ventricles
diencephalon
includes thalamus, hypothalamus, and epithalamus
Tip: THE
- also includes the retina
- associated with the third ventricle
cerebellum
2nd lrgst part of the brain; underneath diencephalon
associated with the 4th ventricle
- similar arrangement as the cerebrum
*2 hemispheres
*cortex: grey matter with many folds called FOLIA
*white matter: tracts called ARBOR VITAE
*deep gray matter
*vermis: connects 2 hemispheres of cerebellum
brain stem
rostral continuation of the spinal cord; consists of the:
- medulla oblongata
- pons
- midbrain: associated with the cerebral aqueduct
medulla and pons associated with 4th centricle