Apixaban

Question 1

What is the therapeutic class of Apixaban?

Answer 1

Anticoagulants

Therapeutic Class: Anticoagulants

Question 2

What is the pharmacologic class of Apixaban?

Answer 2

Factor Xa Inhibitors

Pharmacologic Class: Factor Xa Inhibitors

Question 3

What is the mechanism of action of Apixaban?

Answer 3

Selective inhibits factor Xa, decreasing thrombin generation and thrombus development.

MECHANISM OF ACTION

Question 4

What are some common side effects of Apixaban?

Answer 4

• Bleeding: minor bleeding such as nosebleeds or gum bleeding
• Bruising: more bruising than usual.
• Gastrointestinal issues: nausea or stomach upset.
• Fatigue: Feeling unusually tired and weak.

N4 Common Side Effects

Question 5

What are the indications for Apixaban?

Answer 5

• Reduction of risk of stroke
• Systemic embolism with nonvalvular atrial fibrillation
• DVT prophylaxis after hip or knee replacement surgery
• Deep Vein Thrombosis (DVT)
• Pulmonary embolism (PE)

Indications

Question 6

What are the contraindications for Apixaban?

Answer 6

• Patients hypertensive to drug
• Cautiously in patients at risk for severe bleeding
• Not recommended for patients with severe hepatic impairment
• Not recommended for patients with prosthetic heart valves.
• Bleeding risk is increased in patients with severe renal impairment.

Contraindication

Question 7

What are some adverse effects of Apixaban?

Answer 7

• Epistaxis
• Nausea
• Rectal hemorrhage
• Bleeding Gums
• Hematuria

Adverse Effects